Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep761 | Pituitary and Neuroendocrinology | ECE2022

Skeletal complications in Cushing’s disease (CD)

Miljic Dragana , Djurdjevic Sandra Pekic , Doknic Mirjana , Stojanovic Marko , Djurovic Marina Nikolic , Jemuovic Zvezdana , Radić Nevena , Radovic Sara , Petakov Milan

Introduction: Structural and functional damage of the skeletal system resulting in fractures is a common complication of CD. Due to major effect of glucocorticoids on the trabecular bone, vertebral fractures are a common and severe complication which can lead to disability.Goal: To investigate the prevalence of skeletal complications (osteoporosis, osteopenia, presence of fragility fractures) in patients with Cushing’s disease, as well as gain insig...

ea0067gp37 | Poster Presentations | EYES2019

Calcium infusion test in primary hyperparathyroidism- sensitivity of calcium sensing receptor, possible new theories?

Muzurovic Emir , Pekic Sandra , Djurovic Marina , Miljic Dragana , Stojanovic Marko , Doknic Mirjana , Jemuovic Zvezdana , Vujošević Snežana , Šahmanović Benida , Petakov Milan

Objective: Ionized calcium via calcium sensing receptors (CaSR) mediates feedback inhibition of parat hormone (PTH) secretion. The aim of this study is to evaluate the difference in PTH response during calcium infusion test (CIT), between patients with primary hyperparathyroidism (PHPT) and healthy control (HC).Methods: Study consisted of 15 patients with confirmed PHPT and parathyroid adenoma (57.20±11.38yrs) and 15 healthy subjects-HC (57.20±...

ea0063p236 | Pituitary and Neuroendocrinology 1 | ECE2019

Serum aryl hydrocarbon receptor-interacting protein (AIP) levels are independent of serum GH levels both at baseline and in dynamic tests of GH stimulation and suppression

Stojanovic Marko , Wu Zida , Stiles Craig , Miljic Dragana , Soldatovic Ivan , Pekic Sandra , Doknic Mirjana , Petakov Milan , Popovic Vera , Strasburger Christian , Korbonits Marta

Background and aim: Aryl hydrocarbon receptor-interacting protein (AIP) is evolutionary conserved and widely distributed throughout organism. Broad interest for AIP comes from involvement of loss-of-function AIP mutations in pituitary adenoma pathogenesis. The role of AIP in normal pituitary function is largely unknown. AIP is co-localized with GH in somatotroph secretory vesicles. Serum AIP protein was proteomically identified. We aimed at investigating whether AIP and GH are...

ea0049gp197 | Thyroid 1 | ECE2017

Cognitive functions in primary hypothyroidism on selenium supplementation

Nikolic-Djurovic Marina , Pereira Alberto , Smit Johannes , Vasovic Olga , Jemuovic Zvezdana , Damjanovic Svetozar , Asanin Milika , Pavlovic Dragan , Jankovic Dragana , Pekic Sandra , Miljic Dragana , Stojanovic Marko , Petakov Milan

Introduction: Selenium (Se) is a trace element that plays key roles in thyroid pathology. In patients with Hashimoto thyroiditis (HT), Se supplementation might reduce antibody levels and may provide additional beneficial effects, such as on cognition.Aim: To evaluate cognitive function (cognitive decline) in patients on long-term levothyroxine replacement for primary hypothyroidism with and without selenium supplementation.Design: ...

ea0049ep954 | Pituitary - Clinical | ECE2017

Changes in pituitary tumour biology and behaviour in FIPA patient with GH secreting aggressive pituitary macro adenoma

Miljic Dragana , Pekic Sandra , Doknic Mirjana , Nikolic-Djurovic Marina , Stojanovic Marko , Manojlovic-Gacic Emilija , Korbonits Marta , Trouillas Jaqueline , Vasiljevic Alexandre , Popovic Vera , Petakov Milan

40-year-old female patient presented with acromegaly in 2008 (GH 61 (g/L, IGF-1 774 ng/ml PRL 1500 mU/L). Macro-adenoma invading the right cavernous sinus was found on MRI and she underwent two pituitary surgeries revealing sparsely granulated GH adenoma with scattered PRL cells, low Ki 67 and negative p53 immuno-staining. Her second cousin was treated for macro prolactinoma. Both patients tested negative for germline mutations in the AIP and menin genes. Treatment with somato...

ea0049ep956 | Pituitary - Clinical | ECE2017

Rare causes of hypopituitarism in adults in a tertiary care institution

Djurdjevic Sandra Pekic , Doknic Mirjana , Miljic Dragana , Stojanovic Marko , Djurovic Marina Nikolic , Jemuovic Zvezdana , Stojanoska Milica Medic , Popovic Vera , Petakov Milan

Objective: Hypopituitarism is a rare disease,a pituitary adenoma and is treatment being the most common cause of it. In recent years there is increased reporting of rare causes of hypopituitarism acquired in adulthood, such as other sellar and parasellar masses, brain damage caused by radiation and traumatic brain injury (TBI), vascular lesions, infiltrative/immunological/inflammatory diseases and infectious diseases. Aim of our study was to increase the awareness to these rar...

ea0041ep735 | Neuroendocrinology | ECE2016

Phenotype-genotype analysis in patients with GnRH deficiency in a single center

Djurdjevic Sandra Pekic , Xu Cheng , Dwyer Andrew , Cassatella Daniele , Doknic Mirjana , Miljic Dragana , Stojanovic Marko , Petakov Milan , Pitteloud Nelly , Popovic Vera

Objective: Congenital hypogonadotropic hypogonadism (CHH) results from isolated GnRH deficiency and may present with normal sense of smell (nCHH), anosmia (Kallmann syndrome, KS) or in syndromic forms. Genetic defects are identified in approximately half of CHH cases and oligogenicity is noted in almost 10%. Further, spontaneous reversal of is seen in 15% of patients.Methods: We analyzed the clinical characteristics of 37 Serbian CHH probands (34 sporadi...

ea0070aep737 | Pituitary and Neuroendocrinology | ECE2020

Body composition and bone mineral density in 107 patients with childhood onset growth hormone deficiency (CO-GHD) at the time of transition from pediatric to adulthood endocrine care

Doknic Mirjana , Stojanovic Marko , Milenkovic Tatjana , Zdravkovic Vera , Maja Jesic , Todorovic Sladjana , Katarina Mitrovic , Vukovic Rade , Miljic Dragana , Pekic Djurdjevic Sandra , Soldatovic Ivan , MilanPetako

Transition from childhood to adulthood is a vulnerable period in all adolescents and particularly inCO-GHD patients. Low bone mineral density (BMD) and body composition alterations are frequently reported in young adults with CO-GHD, but relevant large monocentric studies are lacking.Patients and Methods: In a monocentric, observational, retrospective cross-sectional study conducted from 2005–2019, 107 CO-GHD patients were analyzed (17–26 yea...

ea0022p464 | Female reproduction | ECE2010

Kisspeptin levels in high risk pregnancies related to chronic diseases: insulin dependent diabetes mellitus (IDDM) and arterial hypertension (H)

Miljic Dragana , Cetkovic Aleksandar , Ljubic Aleksandar , Patterson Michael , Ghatei Mohammad , Bloom Steven , Djurovic Marina , Doknic Mirjana , Pekic Sandra , Stojanovic Marko , Popovic Vera

Objective: Kisspeptin is hormone involved in the initiation and maintenance of fertility. Placenta is the major source of kisspeptin but its role during gestation is still matter of debate. Studies investigating kisspeptin levels during gestation in patients with diabetes and hypertension are lacking. Our aim was to prospectively evaluate kisspeptin levels in pregnant women with chronic diseases such as IDDM and H.Design and methods: Kisspeptin levels we...

ea0022p558 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Clinically silent pituitary macroadenomas: a clinicopathologic analysis

Djurdjevic Sandra Pekic , Gazibara Milica Skender , Obradovic Angelina , Gacic E Manojlovic , Doknic Mirjana , Miljic Dragana , Djurovic Marina , Stojanovic Marko , Popovic Vera

Background: The so-called silent pituitary adenomas are a subtype of pituitary tumors showing positive immunoreactivity for one or more pituitary hormones, but without any clinical manifestations for oversecretion of these hormones. They are clinically labeled as non-functional pituitary adenomas (NFPA), some of them with particularly aggressive behavior. Rare patients might present with big plurihormonal pituitary tumors which ‘whisper’ hormones (GH or ACTH) and pro...