Endocrine Abstracts

Background: The effect of weight loss on hypothalamic function is complex and not fully understood. There is interplay between neuropeptides (leptin, ghrelin) and hypothalamus with the postulated aim of energy conservation and prevention of pregnancy during unfavourable conditions. We present a memorable case.Case: A 35-yr-old lady presented with secondary amenorrhoea of 17 years duration. She attained menarche at age 13. At age 16 her periods became sca...

The aim of the study is to estimate the efficacy of intravenous corticosteroid therapy in patients with active, sever Graves’ ophthalmopathy.Material and methods: 16 patients with bilateral active, sever Graves’ ophthalmopathy were included to the study. Euthyroididsm has been provided, mean dose of methimasol therapy was 9.4±6.6 mg a day, median of TSH- 0.3 mlU/l, median of fT4 –15.3 pmol/l. The median of duration of GO was 6.5 month...

Both hyperhomocysteinemia and increased inflammatory activity are shown to be associated with atherosclerosis. But, the relation of inflammatory activity to homocysteine levels is not well established. In the present study, we aimed to evaluate the relation of plasma homocysteine (tHcy) levels to atherosclerotic vascular disease and inflammatory activity in type 2 diabetic patients.Ninty type 2 diabetic patients were included in the study. Forty one of t...

We report a case of hungry bone syndrome occured as thyrotoxicosis treated in the patient of Graves disease.The patient was a 37 year-old woman resistant to antithyroid therapy. Radioactive iodine ablation was applied as 10 milicuri. After the serum levels of thyroid hormones decreased to the normal range spontaneous tetany occured.Serum ionised calcium was 4.18 miligram per decilitre(4.25-5.24) and serum phosphate was 2.3 miligram per decilitre(2.5-4.5...

Background & objectives: Vibration perception threshold (VPT) is the gold standard for diagnosis of diabetic peripheral neuropathy. The relationship between symptom severity and VPT remains to be determined. This study evaluated the diagnostic utility of symptoms using the NTSS-6 symptom score vis a vis Bio-thesiometry.Methods: diabetic patients with symptoms suggestive of peripheral neuropathy and 40 apparently healthy controls were studied. Detaile...

Introduction: Patients with life-threatening inborn errors of metabolism are usually managed at specialist care centres. These patients are living longer and some of them have migrated to areas far from their specialist care centres. We present two such cases.Case 1: A 37 year old female with Ornithine Transcarbamylase Deficiency (OTCD), well-managed at a specialist care centre since childhood, relocated a few times before settling down in our area. OTCD...

The role of genetic factors in the pathogenesis of Graves’ disease (GD) is not clear. The purpose of this study was to investigate the association between single nucleotide polymorphisms in pro-inflammatory cytokine genes and GD in Iranian patients. A case–control hospitalbased study was carried out on 107 GD patients and 140 healthy controls. Cytokine typing was performed by PCR with sequence-specific primers (PCR-SSP) assay. The allele and genotype frequencies of t...

Introduction: Primary hyperparathyroidism is associated with insulin resistance and reduced pancreatic beta cell function. Approximately 40% of patients with primary hyperparathyroidism have impaired glucose tolerance. This observational study sought to show improvement in insulin resistance after parathyroidectomy in patients with primary hyperparathyroidism.Methods: Insulin resistance and pancreatic beta-cell function was calculated before and 12 weeks...

A 47-year-old lady presented with a long history of resistant hypertension. Her GP referred her for further investigation to a cardiologist who found a smaller right kidney on ultrasound scan and an elevated rennin level. Renal artery MRA revealed right renal artery stenosis. On September 2008, she underwent right renal artery stenting and was advised to stop taking the antihypertensive medications (doxazosin and amlodipine). A week later she was admitted with headache, vomiti...

Surgery is the most effective way of treating morbid obesity. The laparoscopic gastric bypass (Roux en-Y) is the preferred bariatric surgical procedure performed at our hospital. This combines restriction of intake with a profound sensation of early satiety.Ideally, multi-disciplinary team involvement (including psychological assessment), over a period of at least six months, is a prerequisite for bariatric surgery referral. The more psychotherapeutic wo...