Endocrine Abstracts

Associations of Insulin-like growth factor-II with cardiovascular risk have been inadequately studied. We studied longitudinal associations of IGF-II with cardiovascular risk factors in people with type 2 diabetes. Subjects and methods: 462 type-2 diabetes patients aged 26 to 86 years from the Salford Diabetes cohort were analysed. Longitudinal clinical information was extracted (years 2002–2009) from an integrated database of primary care and hospital data. IGF-II was me...

Insulin-like growth factors have fundamental roles in metabolism and apoptosis. Circulating IGF-I and IGF-II are primarily sequestrated with IGFBP-3 in ternary complexes with the acid-labile subunit. We hypothesized that polymorphisms of the IGFBP3 gene may impact circulating IGF-II concentrations.Methods: 478 Caucasian patients were selected from the Salford Diabetes Cohort for analysis. Thirteen haplotype tagging single nucleotide polymorphisms (SNPs) ...

In Central and Eastern Cheshire, Secondary Care endocrinology/diabetes clinicians can now access a summary of the patient’s primary care electronic patient record (EPR), using a secure Web browser for GP data held by the GP provider EMIS. This improves decision making at the point of care.The clinicians, including consultants, SpRs, dieticians and specialist nurses can access details of medication, allergies, and previous diagnoses, available for 95...

Although non-alcoholic fatty liver disease (NAFLD) patients are rapidly growing, there is not optimal therapy to improve NAFLD. NAFLD is strongly associated with insulin resistance. The peroxisome proliferator-activated receptor (PPAR) activator thiazolidinediones (TZD) is an insulin sensitizer, and have been focused as the drug for NAFLD. However, the TZD remain debate as drug of choice on NAFLD because of its conflicting results on the hepatic steatosis and fibrosis. Lobegli...

ObjectiveSurgery is the only curative treatment for primary hyperparathyroidism. Minimally invasive parathyroidectomy is superior in terms of cure and complication rates and is less costly than inpatient bilateral cervical exploration. Preoperative localization of parathyroid adenoma by imaging is a requirement for outpatient minimally invasive surgery. One of the most frequently used imaging techniques for parathyroid adenoma localization is Tc99m-sesta...

IntroductionEctopic Cushing’s syndrome (ECS) is a rare entity caused by ACTH secretion by a non-pituitary tumor. The management of these patients is challenging due to its low frequency and limited experienced. The objective of this study was to describe the patients with ECS treated in the Division of Endocrinology at the Ramón y Cajal University Hospital (Madrid, Spain) in the last six years.Methods<p class="abstext...

Case history: A 26-year-old female with a past medical history of migraines was admitted to the Emergency Department (ED) with severe hypoglycaemia after drowsiness was noted by her partner in the early hours of the morning. On initial paramedic assessment, the patient had a reduced Glasgow Coma Scale (13/15), hypoglycaemia (capillary blood glucose of 0.9 mmol/l [16.2 mg/dl]), hypothermia (34.3 degrees Celsius [°C]) and bradycardia (heart rate 41 beats per minute). The patient...

Case report: A 55 years old Caucasian gentleman presented with recurrent episodes of unexplained hypoglycaemia with slurred speech, lethargy, myoclonic jerks and seizures. He had background of craniopharyngioma at the age of 17 and underwent surgery but no radiotherapy. Subsequently he was started on hormonal replacement with desmopressin, levothyroxine, hydrocortisone, testosterone and genotrophin and remained stable on treatment for 38 years. Hypoglycaemia work up revealed b...

As optimal postoperative management of patients with clinically nonfunctioning pituitary adenomas (NFPA) is a matter of debate, the role of dopamine agonist (DA) therapy in this clinical setting was evaluated.Methods: Retrospective analysis of prospectively collected data was conducted at two pituitary referral centrer with different standard practices for post-operative management of NFPA: DA therapy or conservative follow up. Dopamine receptor 2 (D2R) ...

Background: In bariatric surgery (BS) patients, nonalcoholic fatty liver disease and fibrosis are present in up to 90% and 24%, respectively. Several fibrosis risk scores have been developed and have been validated in cohorts different from morbid obesity (MO). We aimed to determine whether established liver fibrosis scores were accurate in predicting fibrosis in MO subjects.Material and Methods: Cross-sectional analysis in a cohort of MO patients underg...