Endocrine Abstracts

Inpatients with hyponatraemia have a high mortality and longer length of stay. We instituted a system of automatic referral to the endocrinology team where any inpatient with a serum (Na+) ≤125 mmol/l was referred automatically from their biochemical results.Aims: We evaluated the diagnosis, management, and outcome of the patients referred with hyponatraemia over 6 months.Methods: Data were prospectively captured e...

Hypoglycaemia, a life threatening complication, occurs as part of a wide variety of disease processes. Though a common side effect of diabetes medications, it can be secondary to other factors including, endocrine and, metabolic disorders, severe sepsis, rare malignancies and non-diabetic medications. We present a case series of 3 non-diabetic patients who presented to Princess of Wales, Bridgend with Hypoglycaemic Episodes (HE):1. 23 year old student nu...

Introduction: Anaemia and other haematological disorders have been reported in Turner Syndrome (TS). TS-related comorbidities (premature ovarian insufficiency, autoimmune hypothyroidism, coeliac disease and liver diseases) and treatments (hormone replacement [HRT] and growth hormone) are possible explanations. We aim to investigate the prevalence of abnormal full blood count (FBC) in adult TS and assess associated clinical characteristics.Methods: FBC pa...

Introduction: Long-term increased morbidity and mortality in Turner Syndrome (TS) due to vascular disease is recognized, and suggested risk factors include metabolic parameters and possible change in haemostasis, however elevated red cell parameters in women with TS have not previously been noted.Methods: Following an observation of unexplained occurrence of elevated hemoglobin, a quality improvement-project was conducted to retrospectively review full b...

Introduction: Severe insulinopenic diabetes (SID) is a rare complication of treatment with immune checkpoint inhibitors (ICPI). We describe herein the clinical characteristics, natural history and potential predictors of SID in cancer patients treated with ICPI.Methods: We identified and retrospectively retrieved pertinent clinical data of all patients who presented with new onset SID following treatment with ICPI between 2015 and 2022 at the Tel Aviv-So...

Thyroid storm is rare life-threatening clinical manifestation of endocrine dysfunction originating from excess level of thyroid hormone leading to hypermetabolic state with an incidence of 0.57-0.76/1000,000. The increase demand of metabolic activity subsequently induces, palpitations, dyspnoea, exercise intolerance and congestive heart failure. Most common cardiovascular manifestation of thyroid storm is tachycardia and atrial fibrillation occurs in up to 15% of patients. In ...

Introduction: Intra thyroidal parathyroid adenoma is an uncommon presentation of primary hyperparathyroidism (PHPT). Herein we report such a patient who had recurrent hypercalcemia after a classical parathyroid exploration.Case presentation: 45 year old female, home-maker had a long standing history of weakness, back and lower limb pain, loss of appetite. Preliminary evaluation at secondary care level revealed hypercalcemia (18.3 mg/dl) with high intact ...

Background: Starvation ketoacidosis (SKA) represents one of three metabolic acidosis caused by the accumulation of ketone bodies in blood. While easily treated, it is a diagnosis that can be easily mimic diabetic ketoacidosis, particularly in the presence of hyperglycemia1.Case: We report a 54-year old female, who had been feeling unwell with ongoing nausea and vomiting, and not eating nor drinking for 5 days. She had a history of alcohol exce...

Aim: To assess side effects of testosterone (TRT).Introduction: TRT in men with hypogonadism helps improve libido, erectile dysfunction, energy levels and bone density. However the risks/benefits of TRT in terms of ischemic heart disease (IHD), stroke and venous thromboembolism (VTE) is controversial no definitive answers from current evidence. We evaluated the side effects of TRT in patients attending endocrinology outpatient clinic between 2009 to 2019...

Aim: To compare efficacy of different formulations of TRT in treatment of hypogonadismBackground: Different formulations of testosterone are available for treatment of hypogonadism in men. TRT improves libido, sexual function, bone density and general well-being. We analysed data of 106 patients on TRT to compare efficacy of topical and injectable formulations.Methods: It’s a retrospective data analysis of 106 patient receivin...