Endocrine Abstracts

Background: There is concern that adolescents with childhood-onset GHD (COGHD) and persistent GH deficiency may be exposed to multiple metabolic risks after GH treatment withdrawal at the attainment of final height (FH).Aim: Aim of our study is to retrospectively compare growth response and metabolic profile in isolated idiopathic COGHD adolescents with permanent GH deficiency in comparison to GHD subjects who normalized their GH response at transition p...

Background: Metabolic syndrome (MetS) and peripheral endothelial dysfunction (PED) are both independently associated with an increased risk of cardiovascular disease (CVD). PED provides prognostic information beyond that provided by conventional risk factors. However, the association between MetS and PED remains uncertain. We evaluated the association between MetS and PED.Methods: We performed a retrospective analysis of patients who were referred to May...

Introduction: Alemtuzumab is a humanized monoclonal antibody against CD52, located on the surface of the lymphocytes, used in the treatment of relapsing-remitting multiple sclerosis (RRMS), that can induce novel secondary autoimmune diseases. Autoimmunity may be related to the pattern of T- and B-cell depletion and repopulation following Alemtuzumab treatment. The most frequently reported autoimmune disorders observed with alemtuzumab involve the thyroid gland in up to a third...

Background: The management of subclinical hypothyroidism (SH) is still challenging in particular for mild forms with TSH levels ranging between 4.5 and 10 mU/L. Although SH in children seems to be a bening condition, ongoing scientific investigations have highlighted the presence of subtle proatherogenic abnormalities among children with modest elevations in their TSH levels. Data on cardiac performance in children with SH are still scanty.Aim: To compar...

Introduction: Adrenal myelolipoma is a rare, benign, non-secreting tumor, often found incidentally or in the context of abdominal pain. We report the cases of two patients with adrenal myelolipoma hospitalized at the endocrinology department of diabetology and metabolic diseases of Ibn Rochd University Hospital in Casablanca.Case 1: This is a 30-year-old patient, hospitalized for adrenal mass, revealed by right lower back pain, radiating to the right hyp...

Introduction: The month of Ramadan is characterized by abstaining from drinking and eating from sunrise to sunset. This exposes to an increased metabolic risk in diabetics. However, even if religiously diabetics could be exempt from fasting, a large number of them practice it.Materials and methods: We conducted a cross-sectional study and interviewed diabetic patients about their practices during Ramadan and about the presence or absence of complications...

Introduction: Acromegaly is a clinical syndrome caused by excessive production of growth hormone (GH). It is associated with an increase in the incidence of cancers. Through this observation, we illustrate the rare association of a somatotropic adenoma with a nasopharyngeal carcinoma.Case report: 57-year-old woman, having hypertension, followed for an undifferentiated nasopharyngeal carcinoma since 2011 under radio-chemotherapy, having recurred in Januar...

Introduction: Simple aspiration is the first-line treatment used for benign cystic thyroid nodules. However, a high recurrence rate has been reported with this procedure. When this happens, percutaneous ethanol injection into the nodules has proven to be an effective technique which can reach a volume reduction of about 85% (Kim et al., Eur Radiol. 2012 Jul;22(7):1573–8).Material and methods: Descriptive analysis of percutaneous 96° et...

Introduction: Thyroid dermopathy is a non-frequent manifestation of autoimmune thyroiditis. It complicates a small percentage of patients and is usually associated with ophtalmopathy and acropachy.Observation: A 46-year-old man presented to our department of endocrinology at the university hospital of Casablanca with 3 years history of Graves’ disease, developed gradual onset of exophthalmos and bilateral leg oedema starting from his pretibial areas...

Introduction: Spontaneous thyroid hematoma is a rare entity that can be favored by anticoagulation therapy. Any neck swelling can be life-threatening by compression of the upper aerodigestive tract and adjacent vascular axes.Case report: We report the case of an 80-year-old patient with a previously existing goiter, started on vitamin K antagonists for atrial fibrillation, who presented to the emergency room for anterior neck mass that appeared 2 days be...