Endocrine Abstracts

Background: Preeclampsia (PE) continues tochallenge both the clinicians and researchers worldwide, as the existing knowledge on its etiopathology does not come up with an efficient and foolproof treatment regime due its progressive nature and uncertain diagnosis and prognosis. In this context, miRNAs represent a potential therapeutic target and a diagnostic tool.Objectives: Circulating microRNAs present in maternal blood play an important role in the eti...

Background: Adrenocortical carcinoma in childhood is a rare tumour which accounts for about 0.2% of all paediatric malignancies. Affected children usually present with virilization, cushingoid features, and/or mineralocorticoid excess. We present a boy with adrenal carcinoma presented with virilization and unusually suppressed cortisol at initial presentation.Case report: A two-year-old boy presented with pubic hair, acne, and increased penile growth wit...

Background: Medullary and papillary thyroid carcinomas are distinct entities, regarding their incidence, cellular and genetic origin, histopathological features and prognosis, but there have been described a few cases of the two occurring simultaneously in the same patient. Medullary thyroid carcinoma represents between 1–5% of all thyroid malignancies and it is responsible for 12–13% of all cancer related deaths. The familial form (10–20% of the cases) is cause...

Background/Aim: Radioactive-iodine (RAI) therapy aims to cure hyperthyroidism, with some International authorities recommending a sufficient RAI dose to render patients hypothyroid. An audit on low dose RAI (<400 MBq) at our University Hospital in 2014 suggested above national average rates of Thyrotoxicosis relapse (24%) and lower rates of hypothyroidism (41%) 6-months post RAI. From 2015, a fixed dose (555 MBq) RAI was utilised and we present the audit outcomes using thi...

Actuality: According to WHO, 36% of patients with type 2 diabetes mellitus (T2DM) suffer from obstructive sleep apnoe syndrome (OSAS), which is one of global problems of modern medicine. International classification of sleep disorders identified that 24% of men and 9% of women with T2DM observe symptoms of OSAS. Sleep apnea has a negative effect on the function of the beta cells of the pancreas and insulin sensitivity. Obstructive sleep apnea has a negative impact on the quali...

Background: Cortisol profiles during treatment with standard hydrocortisone (StdHC) formulations are unphysiological. Some patients, with low cortisol levels between doses, experience symptomatic hypocortisolaemia and may benefit from modified release hydrocortisone (MRHC). Plenadren is a MRHC licensed for once daily dosing in adults.We offered Plenadren to patients with symptomatic hypocortisolaemia, documented to occur at times of low cortisol levels, ...

Introduction: Hypercalcemia associated with the use of a SGLT-2 inhibitor is a very rare adverse effect. Herein we reported a case of apparent primary hyperparathyroidism that occurred while applying the treatment of dapagliflozin in a patient with asymptomatic primary hyperparathyroidism.Case report: A 49-year-old male patient with 5 years of diabetes mellitus history admitted for his routine control and Hba1c level was observed 7.9%. Dapagliflozin (1 &...

Background: Endocrine-related adverse effects of immune check-point inhibitors (ICIs) have been identified in growing number of cancer patients.Case presentation: A 49-year-old male with laryngeal cancer applied to ouroutpatient clinic with weakness, loss of appetite, weight loss, nausea and vomiting for the last three weeks. He was diagnosed with T3N1M0 laryngeal squamous cell cancer seven months before this admission and was given concurrent cisplatin ...

Background: Amongst hospitalised patients, hyponatraemia is the commonest electrolyte abnormality with reported prevalence of about 25%. Its association with mortality, morbidity and increased length of stay is well recognised, including adverse fracture risk and falls with mild hyponatraemia in elderly. We audited the management of hyponatraemia in inpatients in a University hospital setting.Methods: Over a 3-month period, amongst all in-patients, we id...

Hypothalamic obesity has major impact on prognosis and quality of life (QoL) in childhood craniopharyngioma (CP). The pathogenic relevance of initial hypothalamic involvement versus treatment-related hypothalamic lesions is a matter of controversy.One hundred and twenty patients were recruited prospectively during 2001 and 2007 and evaluated after 3 years of follow-up. Body mass index (BMI) and QoL at diagnosis and 36 mo after diagnosis were analyzed bas...