Endocrine Abstracts

Background and objective Hyponatraemia is a common metabolic disorder with a significant morbidity and mortality, especially in the elderly. However, its significance is often ignored, and when found, inadequately investigated and inappropriately managed. The objectives of this audit were to investigate the investigations and management of hyponatraemia in a large District General Hospital.Methods From the bi...

Introduction:Amiodarone is a life saving anti arrhythmic drug,but it has a complex side effect profile involving organs that include thyroid,lungs, liver and eyes. It is well known that patients on long term amiodarone therapy should be followed up in a structured manner including regular thyroid function tests,liver function tests,chest xray and eye examination.There are guidelines suggested by the Summary of Product Characteristics (SPC) for amiodarone...

Introduction. We present a rare and unusual case of direct trauma to the pituitary region.History. A 22 year old female, 8 weeks post-partum, fell downstairs on to a metallic clothes drier. A metal spike 3mm wide and approximately 20cm long penetrated her right eyebrow. Computed tomography showed a haemorrhagic track involving the hypothalamic region, and extending to the left internal capsule. Irritability and instability of vital signs necessitated in...

Background: In acromegaly, carbohydrate metabolism disorders (CMD) are frequently observed. The effect of therapy of acromegaly on pathogenesis of CMD is not clear.Aim: To assess the effect of somatostatin analogues (SSA) on pathogenesis of carbohydrate metabolism disturbance in acromegaly.Patients and methods: 103 acromegaly patients were examined (31 men, 72 women; age 54 (46–61) years; 60 had newly diagnosed acromegaly (NA)...

Background: In acromegaly, carbohydrate metabolism disorders (CMD) are frequently observed. We aimed to assess the differences in insulin secretion and sensitivity depending on stage of the disease and type of treatment.Design: Sixty-four patients with acromegaly (46 women; age 53 (interquartile range, IQR 47–59) years), of whom 29 were newly-diagnosed (NA group), 20 treated with somatostatin analogues (SSA group) and 15 after transsphenoïdal s...

Introduction: Vitamin D is important for bone and muscle development, function, and preservation. The serum 25OHD concentration is the best available clinical indicator of vitamin D status. The optimal serum 25OHD concentration is considered to be that level associated with maximal parathyroid hormone (PTH) suppression.The aim: To determine the frequency of vitamin D deficiency and insufficiency in patients of different region of Ukraine and to evaluate ...

The global warming and its impact on the summer average temperature elevation, in the south-eastern parts of Europe, represent an inevitable stress for living organisms in this region. Heat stress was shown to be the strongest one, when compared to immobilization or cold stress. Activation of the hypothalamo-pituitary–adrenal (HPA) axis during exposure to various types of stressors is well-known physiological concept. The effect of 24 h exposure to heat stress on the morp...

Somatostatin analogues (SSA) represent a recognized therapeutic option in patients affected with functioning neuroendocrine tumors (NET). In non-functioning NET, SSA are reported to induce tumor stabilization in most of cases and objective response in <5%. NET associated to Multiple Endocrine Neoplasia type 1 (MEN1) are inherited tumors, generally located in the duodeno-pancreatic trait, characterized by well differentiated histotype, high expression of somatostatin recept...

Introduction: XX male syndrome is a disorder of sex development associated with a 46, XX karyotype and is characterized by such features as: small testes, hypergonadotropic hypogonadism, male external genitalia, gynecomastia and azoospermia. The estimated prevalence is 1/20.000 males. Gender role and gender identity are reported as male. Identification and subsequent treatment is necessary to avoid the manifestations of testosterone deficiency.Clinical C...

Introduction: Reduced health-related quality of life (HRQoL) is common in patients with chronic hypoparathyroidism treated conventionally with active vitamin D and calcium supplements.Aim: To determine the HRQoL of patients with hypoparathyroidism with disease persisting for more than 1 year.Methods: We identified 32 patients (women/men − 31/1, median (Me) age 48 years [38; 59.5]). The average duration of the disease was 4 ye...