Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep813 | Obesity | ECE2016

Continuous glucose monitoring for evaluation of glycemic variability after bariatric surgery

Martins Diana , Cardoso Luis , Baptista Carla , Rodrigues Dircea , Barros Luisa , Vicente Nuno , Oliveira Diana , Lages Adriana , Ventura Mara , Carrilho Francisco

Introduction: Neuroglucopenic hypoglycaemia might be an underestimated threat of bariatric surgery, as Roux-en-Y gastric bypass (RYBG) or gastric sleeve. We aimed to evaluate glucose variability after bariatric surgery by continuous glucose monitoring (CGM) in a real-life setting.Methods: CGM was used in twelve patients with clinical suspicion of hypoglycaemia after undergoing bariatric surgery (RYBG or sleeve), during seven days. CGM was through using i...

ea0041ep902 | Pituitary - Clinical | ECE2016

Craniopharyngiomas–35 years of experience in a central hospital’s Endocrinology Department

Oliveira Diana , Paiva Isabel , Guelho Daniela , Cardoso Luis , Vicente Nuno , Martins Diana , Lages Adriana , Ventura Mara , Paiva Sandra , Carrilho Francisco

Introduction: Craniopharyngiomas are rare epithelial tumors of the sellar and parasellar region, with high survival rates but with frequent tumor recurrence or persistence.Methods: Information collection from clinical records and review of the epidemiology, diagnosis, treatment and follow-up of patients with diagnosis of craniopharyngioma followed in an Endocrinology Department between 1980 and 2015. Statistical analysis using SPSS v. 22.0.<p class="...

ea0037ep388 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Contribution of glucose variability to HbA1c levels in patients with type 1 diabetes

Cardoso Luis , Batista Carla , Rodrigues Dircea , Moreno Carolina , Guelho Daniela , Vicente Nuno , Balsa Margarida , Martins Diana , Oliveira Diana , Carrilho Francisco

Background: Optimal management of type 1 diabetes requires full understanding of the relationships between the triad: HbA1c, fasting plasma glucose, and glucose variability (GV). As GV may contribute to HbA1c we assessed the influence of GV in HbA1c levels.Research design and methods: We retrospectively analysed 9393 h of continuous glucose monitorings (CGMs) from 61 patients with type 1 diabetes. Periods of 24 h with missing values were excluded. We cal...

ea0037ep818 | Pituitary: clinical | ECE2015

Post-operative serum cortisol levels as predictors of recurrence in Cushing's disease

Martins Diana , Guelho Daniela , Paiva Isabel , Baptista Carla , Vicente Nuno , Cardoso Luis , Oliveira Diana , Balsa Margarida , Carrilho Francisco

Introduction: Cushing’s disease (CD) is characterized by increased secretion of ACTH often as a result of a pituitary adenoma. The surgical success rates after transsphenoidal pituitary surgery (TSS) range from 53 to 96% in different centres. Postoperative cortisol levels have been proposed as the standard criteria for prediction of surgical remission however, this variable is subject of a variety of interferences.Objectives: Evaluate the potential ...

ea0037ep819 | Pituitary: clinical | ECE2015

Endocrine manifestations of Langerhans cell histiocytosis

Cardoso Luis , Gomes Leonor , Rodrigues Dircea , Moreno Carolina , Guelho Daniela , Vicente Nuno , Balsa Margarida , Martins Diana , Oliveira Diana , Carrilho Francisco

Introduction: Langerhans cell histiocytosis (LCH) is a rare disorder characterized by proliferation/accumulation of cells phenotypically similar to skin Langerhans cells. Clinical presentation and aggressiveness are very heterogeneous, from benign to disseminated forms that cause significant morbi-mortality, particularly endocrine failures.Case 1: A 15-year-old Caucasian woman presented with a 14-month history of headaches, secondary amenorrhea. She repo...

ea0037ep1303 | Clinical Cases–Thyroid/Other | ECE2015

Medullary thyroid carcinoma in multiple endocrine neoplasia 2A: a therapeutic challenge

Cardoso Luis , Rodrigues Dircea , Costa Gracinda , Moreno Carolina , Guelho Daniela , Vicente Nuno , Balsa Margarida , Martins Diana , Oliveira Diana , Carrilho Francisco

Introduction: Medullary thyroid carcinoma (MTC) occurs in a hereditary pattern in 25% of cases. Virtually all patients with multiple endocrine neoplasia 2A (MEN2A) develop MTC. MTC aggressiveness and natural history varies according to the RET mutation. Prophylactic thyroidectomy may cure and/or prevent metastatic disease in most cases.Case report: A 27-year-old man with past history of colostomy at 5 months of age for Hirschsprung disease and t...

ea0035p296 | Clinical case reports Thyroid/Others | ECE2014

Type 2 polyglandular autoimmune syndrome and Turner syndrome

Moreno Carolina , Rodrigues Dircea , Vieira Alexandra , Ruas Luisa , Saraiva Joana , Guelho Daniela , Cardoso Luis , Vicente Nuno , Carrilho Francisco

Introduction: Individuals with Turner syndrome (TS) are prone to develop autoimmune conditions. The most frequently found are Hashimoto’s thyroiditis, type 1 diabetes, coeliac disease, and inflammatory bowel disease. In patients with TS, Addison’s disease isolated or combined with other autoimmune disease as type 2 polyglandular autoimmune syndrome, is a rare finding.Case report: We report a case of a 41-year-old female patient, with severe ast...

ea0035p325 | Clinical case reports Thyroid/Others | ECE2014

Hypoglycemia in type 1 diabetes mellitus patient – factual ou factitious?

Guelho Daniela , Paiva Isabel , Rodrigues Dircea , Baptista Carla , Saraiva Joana , Moreno Carolina , Dantas Rosa , Vicente Nuno , Cardoso Luis , Carrilho Francisco

Introduction: Factitious hypoglycemia results from surreptitious administration of insulin or insulin secretagogues. It can involve non-diabetic individuals with knowledge of hypoglycemiant drugs, or diabetics manipulating the doses.Clinical case: A 42-year-old women, type 1 diabetic since the age of 14, on intensive insulin therapy (A1C: 8.5%), was hospitalized for study of recurrent severe hypoglycemia in the last 2 months, despite successive insulin d...

ea0035p1008 | Thyroid (non-cancer) | ECE2014

Recurrence of Graves' disease after radioiodine treatment: factors related to treatment failure

Moreno Carolina , Pires Luis , Cardoso Luis , Ruas Luisa , Saraiva Joana , Guelho Daniela , Vicente Nuno , Costa Gracinda , Carrilho Francisco

Introduction: Radioiodine (RAI) therapy is an inexpensive and reliable therapeutic option for Graves’ disease (GD). However, individual characteristics of the disease can influence therapeutic success. The identification of these factors may help to predict outcome and select optimal pre-treatment conditions.Aim: To assess clinical, laboratory and radioactive parameters that may lead to RAI treatment failure in patients with GD....

ea0035p1009 | Thyroid (non-cancer) | ECE2014

Severe side effects of methimazole in the treatment of hyperthyroidism

Moreno Carolina , Alves Marcia , Paiva Isabel , Rodrigues Dircea , Ruas Luisa , Saraiva Joana , Guelho Daniela , Vicente Nuno , Cardoso Luis , Carrilho Francisco

Introduction: Methimazole is the thionamide compound most used in the treatment of hyperthyroidism due to its efficacy, commodity and security. Severe side effects are rare, although potentially fatal: agranulocytosis in 0.1–0.5% and toxic hepatitis in 0.1%Aims: To characterize the patients admitted in the endocrinology ward for the last 10 years for severe complications of methimazole therapy.Material and Methods: Retrospecti...