Endocrine Abstracts

Purpose: Radiation-induced anterior pituitary hormone deficiencie is the most common long-term complications of successful cancer treatment. The aim of our study was to analyze thyroid status in young adults after radiotherapy in childhood and their relationship with dose of radiotherapy.Materials and methods: Thyroid function (TSH, free T4, free T3) and thyroid ultrasound were evaluated in 29 young adults with a history of radiotherapy for brain tumors ...

Introduction: Iodide administration is generally recommended in combination with anti-thyroid drugs when a rapid return to normal thyroid hormone levels is required, such as in the treatment of patients with ‘thyroid storm’. However, there are few reports concerning the combination therapy for many patients with Graves’ hyperthyroidism. In this paper, we studied the effects of potassium iodide (KI) combined with 15 mg of methimazole (MMI) to the initial treatmen...

Objective: To investigate the influence of vitamin E (VE) and selenium (Se) on apoptosis of human thyrocyte induced by H2O2.Methods: The human thyroid epithelium cells (TEC) from normal para-adenoma tissues of patients with thyroid adenoma resection were cultured. In prevention groups, vitamin E (50 μmol/l), selenium (10–7 mol/l) or serum-free medium was respectively added into thyrocytes of monolayer culture before H...

Introduction: We investigated short-term influence of thyroxin replacement therapy on blood pressure (BP) and cardiovascular status in patients with first identified primary hypothyroidism (PH) and earlier diagnosed arterial hypertension (AH).Methods: 52 patients with PH and AH were observed twice: prior to replacement therapy and after reaching euthyroid status. All patients underwent daily BP monitoring, echocardiography, and high frequency ultrasound ...

Introduction: Hashimoto’s thyroiditis can be accompanied by thyroid cancer. It is reported that there is an association between selenium deficiency and thyroid cancer. In addition, it is known that chronic inflammation is another causal factor in the etiology of cancer.In this study, we aimed to determine whether selenium or oxidative stress is a modifying factor for the association between Hashimoto’s thyroiditis and cancer.<p class="abste...

Polycystic ovary syndrome (PCOS) is characterized by laboratory and/or clinical features consisting of hyperandrogenism with chronic anovulation. and is currently one of the most common endocrinopaties in women of fertile age. PCOS is associated with a variety of endocrine and metabolic disturbances. It is well known that women are more prone to develop autoimmune diseases compared to men and levels of sexual hormones are thought to be responsible for such a difference. Our ai...

Dehydroepiandrosterone (DHEA) has been suggested to have an anti-obesity effect; however, the mechanism underlying this effect remains unclear. The effect of DHEA on adipocytes opposes that of glucocorticoids, which potentiate adipogenesis. The key to the intracellular activation of glucocorticoids in adipocytes is 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which catalyses the production of active glucocorticoids (cortisol in humans and corticosterone in rod...

Background: Asian has higher prevalence of diabetic nephropathy and end-stage renal disease as compared to Caucasian. No study to date has evaluated whether multifactorial intervention was associated with remission of microalbuminuria in type 2 diabetic Asian population. We evaluated the effect of tightly controlling multiple factors on the remission of diabetic nephropathy in type 2 diabetic Chinese with microalbuminuria.Materials and methods: A total o...

Background: Oxytocin is a nonapeptide hormone synthesized in the supraoptic and paraventricular nuclei of the hypothalamus. Oxytocin has an effect on uterine smooth muscle contraction, blood pressure, memory, learning capability, nursing, sexual and feeding behavior. Oxytocin and vasopressin stimulate the release of insulin and glucagon from the rat pancreas. Multi organelle effects of oxytocin make it as important hormone in body.Objective: The aim of t...

Patients with craniopharyngioma are frequently obese with a high prevalence of vascular morbidity. Many patients with treated craniopharyngioma have severe GH deficiency (GHD), which independently results in abnormal body composition and increased cardiovascular risk. This study investigated how GH treatment influences body composition in adults with treated craniopharyngioma and GHD.Using the electronic database Diabeta3® we identified 50 patients ...