Endocrine Abstracts

A 36-year-old female patient was referred to endocrinology outpatient clinic due to increased TSH levels. Two years ago, she had been diagnosed and treated as Graves’ disease with propylthiouracil. Total thyroidectomy was performed in another center due to ineffective medical treatment and oral levothyroxine sodium (LT4) was started. During the follow-up her TSH levels were normal. Thirteen months after the last normal TSH value, she consulted the endocrinology outpatient...

Current therapies for locally advanced or metastatic prostate cancer aim to inhibit androgen receptor (AR) activation directly or by depleting androgens via androgen deprivation therapy. However this therapeutic approach eventually fails in ~80% of patients, leading to development of castrate resistant prostate cancer (CRPC). There are currently few therapeutic options available for CRPC with limited prognostic or predictive biomarkers. The aim of the current study was to dete...

Thyroid cancer is one of the common head and neck malignancies and may be found incidentally with other head and neck cancers. The purpose is to evaluate the prevalence and risk of malignancy in incidental thyroid lesions identified by ultrasound (US) in patients with head and neck cancer. We retrospectively reviewed medical records of all patients with head and neck cancer other than of thyroid origin between January 2004 and January 2012. A total of 697 patients (542 men and...

Several preparations of thyroxine are available nowadays but is a great challenge for every clinician when the oral and intramuscular administration is failing and has to consider long term intravenous administration. This is a 42 years old lady who had a total thyroidectomy for Graves thyrotoxicosis. She commenced on multiple oral preparations of thyroxine and liothyroxine with no biochemical response. This is not a case of pseudomalabsorption as oral absorption studies of hi...

Introduction: In this study, we aimed to evaluate radioiodine (RAI) treatment efficacy in geriatric patients with hyperthyroidism.Design: Patients older than 65 years who received RAI treatment were included via retrospective data analyses. Eighty-two patients with hyperthyroidism (average age: 69.9 years, age range: 64–81 years) who received RAI treatment and then followed up for at least 6 months were included in the study. Patients’ clinical...

11β-Hydroxysteroid dehydrogenase type one (11β-HSD1) converts inert glucocorticoids to active forms, amplifying intracellular glucocorticoid action. 11β-HSD1 also catalyses the reduction of seven-ketocholesterol (7KC) to 7β-hydroxycholesterol (7βHC). 7KC may inhibit cholesterol biosynthesis (Brown et al. 2002). Alteration of cholesterol homeostasis is a major atherosclerotic risk factor. 11β-HSD1 deficiency/inhibition is atheroprotective ...

Klinefelter syndrome (47XXY male) (KS) is the most common sex chromosome disorder in men. The phenotype is diverse including: infertility, hypogonadism, impaired cognition, behavior disorders, increased autoimmunity and osteopenia. We have studied osteopenia, learning dysfunction, germ cell loss, and testosterone deficiency in 41 XXY mice bred by two separate methods. We have characterized the germ cell loss by apoptosis and germ cell migration as the mice progress from day 1 ...

Objectives: Secretion of GH, a pituitary and anabolic hormone that reduces visceral fat, is diminished in obese or elderly subjects. The reduced GH may induce visceral fat accumulation and subsequently accelerate metabolic syndrome in these population. In the present study, we sought the effect of chronic GH supplement on visceral fat and glucose metabolism in diet-induced obese (DIO) mice.Methods and results: Male obese mice (C57BL/6, 12 weeks old) unde...

Introduction: The molecular basis of exocytosis of secretory insulin-containing granules (SGs) during biphasic glucose-stimulated insulin secretion (GSIS) of pancreatic β-cells remains unclear. Syntaxins (Syns) Syn-1A and Syn-4 are t-SNARE proteins situated on the plasma membrane that have been well studied to mediate insulin exocytosis. However, Syn-3, peculiarly more abundant in insulin SGs, has unclear function in GSIS.Methods/Designs: Confocal m...

Background: The study aimed to evaluate quality-of-life (QoL) aspects and impact of vitamin D deficiency in primary hyperparathyroidism (pHPT).Method: 150 consecutive patients (119 women) with pHPT (mean age 60±11 years; BMI 27±5 kg/m2; ionized calcium 1.44±0.08 mmol/l; PTH 130±69 ng/l) were included. Six weeks postoperatively, the pHPT patients were reexamined and randomized (double-blind) to daily substitution with calciu...