Endocrine Abstracts

Introduction: Thyroid disorders affect metabolism and body composition; however, literature data have been conflicting on whether this is also the case for thyroid hormone levels within the euthyroid range. Therefore, we have investigated the relationship between indices of thyroid status and both body composition and metabolic parameters in a population of healthy euthyroid men.Methods: Healthy male siblings (n=941, 25–45 years, median BMI 2...

Introduction: Hyperthyroidism with diffuse goiter and negative TBII includes Graves’ disease in the early stage or near remission and nonautoimmune hyperthyroidism (NAH) caused by constitutively activating germline mutations of TSH receptor. To verify the NAH in this situation, we examined TSH receptor mutation and followed-up the clinical course.Patients and methods: From 2003 through 2011, 84 patients had hyperthyroidism with negative TBII and dif...

We reported the isolation and structural characterization of CPF-AM1 and other peptides from the skin secretion of Xenopus amieti. This study investigated the insulin-releasing activities of synthetic CPF-AM1 using clonal pancreatic cell line, BRIN-BD11 and Swiss TO mice with diet-induced insulin resistance.Acute insulin-release studies were performed in Krebs Ringer bicarbonate buffer supplemented with 5.6 mM or 16.7 mM glucose, purified synthetic pepti...

Introduction: Mesenchymal bone marrow cells (BMCs) contain pluripotent progenitor cells, which differentiate into multiple lineages. In a previous study, we reported that adenovirus-mediated forced expression of steroidogenic factor-1/adrenal 4 binding protein (SF-1/Ad4BP), an essential nuclear receptor for steroidogenesis, could transform human BMCs into steroidogenic cells, suggesting a possibility of cell transplantation therapy in patients with steroid deficiency. In this ...

Introduction: Left ventricular hypertrophy (LVH) is associated with increased morbidity and mortality. LVH defined by ECG (ECG-LVH) has been evaluated using standard voltage criteria by Sokolow and Lyon (SL-LVH) and more recently using the Cornell product criteria (CP-LVH). Evaluation of CP-LVH is beneficial in hypertensive patients: however, in patients with primary aldosteronism (PA) whose incidence of cardiovascular events is higher than essential hypertension (EHT), there ...

Objective: To assess the effects of hormone replacement therapy on bone mineral density (BMD), biochemical markers of bone turnover, and lipid profiles in postmenopausal women.Methods: We retrospectively reviewed the medical records of 199 postmenopausal women who had received care at the Department of Obstetrics and Gynecology of Catholic University Seoul St. Mary’s Hospital between January 1994 and December 2008. The patients were divided into the...

Background: The results of studies evaluating the relationship between serum 25-hydroxyvitamin D (25OHD) with intact PTH (iPTH), calcium (Ca) and phosphorus (P) levels are controversial.Objective: To determine the diagnostic values of iPTH, Ca and P for the prediction of vitamin D deficiency.Methods: We analysed iPTH, Ca and P levels in otherwise healthy 700 subjects (619 (88.4%) female, 81 (11.6%) male, mean age 47.44±16.58 y...

Cardioprotective actions of urocortin (Ucn) I have been proposed by several studies and may play a critical role on stress adaptation. And one of the beneficial actions on cardiovascular cells may be anti-oxidative actions. In addition, Ucn I may be regulated by oxidative stress, therefore, the present study is designed to reveal anti-oxidative actions of Ucns on cardiomyocytes. Mouse atrial cell line, HL-1 cardiomyocytes, was cultured in standard Claycomb medium supplemented ...

Background: Dyslipidemia is a well-known manifestation of thyroid dysfunction and there is evidence of an association between hypothyroidism and coronary heart disease. Recently, small dense low-density lipoprotein (sdLDL) has been linked with development of cardiovascular disease. But relations between thyroid function and sdLDL remain incompletely understood.Objective: Our objective was to determine whether replacement therapy with thyroxine for patien...

Introduction: Only few cases of true hermaphroditism with male phenotype and 46,XX/ 47,XXY Klinefelter’s mosaic karyotype with clinical features different among cases have been previously described.Case report: A 12-year-old patient was referred to our clinic for mixed gonadal dysgenesis. Since birth he has ambigous genitalia: unilateral criptorchidism on the right and perineal hypospadia; left gonad was palpable in the scrotum since birth. At the a...