Endocrine Abstracts

Background: The case is a 64 year old patient referred by the GP who noticed she looked ‘cushingoid’. She gave an approximately 4 year history of a change in facial complexion, central weight gain, unsteadiness and poor wound healing. There was a history of depression, essential hypertension and previous back surgery. On examination she was plethoric, had pedal oedema, thin skin and central obesity (BMI 32).Investigations: Initial overnight dex...

Case: A 73 year old man was seen in eye clinic with 5 month history of visual problems. He was diagnosed with bilateral glaucoma and early Cataracts. His vision was not improving despite eye drops and new glasses thus cranial imaging was requested. He also complained of feeling off balance and tiredness. He denied headache or galactorrhoea. Examination: Bitemporal hemianopia (L>R). Investigations: CT head scan – Pituitary Macroadenoma 3.6×3.1×3.8 cm, with di...

Introduction: Treculia Africana (TA) has been used as an anti-inflammatory agent by the Yoruba people of West Africa and is also known to be a component of an ancient anti-diabetic remedy used in the Western and Middle belt areas of Nigeria. This study was conducted to investigate the anti-hyperglycemic property of the aqueous seed extract of Treculia Africana (TAE) and also to evaluate the potential of this extract in reversing the toxicity inflicted by expe...

Introduction: Cord blood gases are measured following partition and are used as surrogate markers in the assessment of fetal oxygenation status at delivery and in identification of risk for neonatal encephalopathy. Low maternal prolactin levels were associated increased risk of respiratory distress syndrome. This study measured cord blood prolactin levels and correlated values with blood gases to examine possible value in assessment of fetal stress during deli...

A 16 year old boy presented to his GP with a two month history of polyuria and polydipsia. He was reviewed by his GP and diabetes mellitus was ruled out. At the time of presentation three months later, he had a three week history of headache and vomiting. His glasses prescription had changed and he had increasing diplopia. The optician found bilateral papilloedema and he was referred to the eye clinic for further assessment. Due to abnormal gaze palsies, he was admitted to the...

Background: A 59 year old man was referred to Endocrinology from Neurology with a 2 year history of hypertension, and a 1 year history of mild hypernatraemia (146–148 mmol/l) and hypokalaemia (3.2–3.4 mmol/l). He had a past history of a cerebral aneurysm and superficial siderosis. His main complaints were severe fatigue, poor balance and tinnitus. His medications at diagnosis were Amlodipine 5 mg and Sertraline 50 mg.Investigations: Blood press...

Background: A 59 year old woman presented with recurrent symptoms of catecholamine excess (episodic headache and sweating). She was initially diagnosed in another centre to have a right adrenal phaeochromocytoma in 2002. She had suggestive symptoms, elevated urine catecholamines and a right adrenal mass on CT Adrenals. MIBG was however negative and they had proceeded with a right adrenalectomy and histology confirmed a phaeochromocytoma. She also had type 2 DM, anxiety and deg...

Background: Conventional management for thyrotoxicosis includes anti-thyroid medications, radioactive iodine and/or surgery. However, in some cases patients are resistant to first line drugs and need second line treatment to normalize thyroid function tests (TFTs) before considering definitive therapy. We present a case of Grave’s disease where patient didn’t respond to first line anti-thyroid medications and required Lithium and Cholestyramine to achieve euthyroid s...

A 45 year old man was referred to endocrinology with increasing weakness, lethargy, loss of libido and erectile dysfunction. Initial investigations showed hypogonadotrophic hypogonadism with testosterone 0.8 nmol/l (8.2–32.2), FSH <1 U/l, LH<1 U/l, SHBG 93 nmol/l and secondary hypothyroidism with TSH 1.65 mU/l, FT3 2.1 pmol/l FT4 9 pmol/l, prolactin 180 mU/l, IGF-1 12.5 nmol/l. Short synACTHen test showed normal adrenal response (692 to 1014 nmol/l) with a higher ...

Objectives: This study was undertaken to ascertain the prevalence of hearing loss (HL) in patients with Type 2 Diabetes (T2DM) and to understand its relationship with diabetic neuropathy.Materials and Methods: Patients between the ages of 30 to 60 years (both ages inclusive) with T2DM were recruited and divided in two groups. Group 1 with moderate to severe distal sensory-motor neuropathy (Michigan Diabetic Neuropathy Score >12) or Group 2 were those...