Endocrine Abstracts

Aim: Endocrine Society (2016) published guidelines for hormonal replacement in hypopituitarism. Central hypothyroidism (CH) is defined as fT4 below reference range and mild CH is defined as fT4 in the low-normal range with suggestive symptoms in the context of pituitary disease. In patients with panhypopituitarism levothyroxine in doses sufficient to achieve fT4 levels in the upper half of the reference range is recommended. In our centre...

Case: A 79 years old frail lady with history of dementia and hypertension presented with refractory hypoglycaemia over a period of 3 months requiring multiple admissions. During her most recent admission, she required continuous dextrose infusion to maintain euglycaemia. The severe spontaneous hypoglycaemia in this non-diabetic lady, warranted a series of investigations. TFT and Short Synacthen Test excluded thyroid dysfunction and hypoad...

Aims: Endocrine Society (ES) acromegaly guidelines (2014) addressed complication screening. Uncontrolled acromegaly is associated with elevated cardiovascular mortality due to risk factors including hypertension (HT), diabetes mellitus (DM), obstructive sleep apnoea (OSA), and with an increased risk of colorectal cancer and polyps among other types of neoplasias. We audited our clinical practice with regards to acromegaly complication screening.Methods: ...

Aim: Endocrine Society (2016) published guidelines for hormonal replacement in hypopituitarism. Central hypothyroidism (CH) is defined as fT4 below reference range and mild CH is defined as fT4 in the low-normal range with suggestive symptoms in the context of pituitary disease. In patients with panhypopituitarism levothyroxine in doses sufficient to achieve fT4 levels in the upper half of the reference range is recommended. In our centre...

Case: A 79 years old frail lady with history of dementia and hypertension presented with refractory hypoglycaemia over a period of 3 months requiring multiple admissions. During her most recent admission, she required continuous dextrose infusion to maintain euglycaemia. The severe spontaneous hypoglycaemia in this non-diabetic lady, warranted a series of investigations. TFT and Short Synacthen Test excluded thyroid dysfunction and hypoad...

Background: The accuracy of thyroglobulin (Tg) as a tumour marker following lobectomy for differentiated thyroid cancer (DTC) remains controversial. A Tg (<10 µg/l) looked promising in identifying those without clinically apparent recurrence after median 51 months of follow-up. Longer term follow up allows assessment of the diagnostic utility of thyroglobulin in predicting relapse.Methods: Ninety-nine patients who underwent lobectomy for DTC wer...

Introduction: There is great variation in management of perioperative cortisol management in patient’s undergoing pituitary surgery across UK Hospitals. We evaluated safety and effectiveness of standards followed in ARI. The aim of audit was to confirm safety, improve knowledge and change practice for better patient care if needed based on information gained from the available data.Description of methods/design: We evaluated 30 patients who have und...

Several studies indicated that estrogen receptors (ERs) and vitamin D receptor (VDR), as well 1α-hydroxylase 25-hydroxy vitamin D (1OHase) are expressed in various normal and cancerous cell types. To date, there are no reported studies on the different expressions of VDR, 1OHase and ERs, in human thyroid normal and cancer cells. This study addresses these questions. Tissues harvested from papillary thyroid cancer (PTC) and normal glands explants were used throughout eithe...

Introduction: Low dose radioiodine (LDRAI) has been used to treat benign thyroid disease for over 70 years (1). However, controversies remain about the optimal dosage to administer. The Royal College of Physicians guidelines recommend a dosage of 400–600 MBq for uncomplicated Graves’ disease (2); the dose administered varies between centres.Methods: Outcome data at Edinburgh Royal Infirmary were collected retrospectively for patients who receiv...

Introduction: Diabetes Insipidus (DI) is the inability of the kidneys to concentrate urine. This is due to decreased production of Anti-diuretic Hormone (ADH) from the posterior pituitary gland (cranial DI) or decreased tubular sensitivity to ADH (nephrogenic DI) or a mixed picture.Case: A 53-year-old male presented with several-months history of polyuria and polydipsia. He had constant thirst and had to void urine four times at night. He did not have di...