Endocrine Abstracts

Hashimoto’s encephalopathy (HE) is a very rare neuropsychiatric condition associated with autoimmune thyroid disorders which shows a remarkable response to steroid therapy and hence is also called steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT). We report a case of 44 year old lady presenting twice with psycho-affective symptoms but not receiving the diagnosis on first presentation. She initially presented with 3 wee...

Introduction: Diabetes is a chronic condition which has become a major public health concern approaching epidemic proportions globally. Effective diabetes management often presents many challenges. Clinicians and patients often become overwhelmed by the need to address co-morbid chronic conditions in addition to patients’ diabetes-specific treatment goals. It is widely accepted that bariatric surgery can help improve health in a range of metabolic diseases, including T2D...

Introduction: We report a case of adrenal insufficiency as the first clinical manifestation of antiphospholipid syndrome.Case report: A 56-year-old male with no previous history of thrombosis was admitted with 3 stone weight loss and feeling generally unwell. He was hypotensive, pigmented and had a slate grey pigmentation of the nose. Chest auscultation revealed reduced breath sounds. Investigations revealed low sodium and high potassium levels with meta...

Introduction: Hypothyroid myopathy with moderate elevation of muscle enzymes is not uncommon. However rhabdomyolysis and acute renal failure due hypothyroidism is rare and only few cases have reported. We describe a patient with rhabdomyolysis due to primary hypothyroidism.Case report: A 45-year-old male was admitted with 6 weeks history of generalised muscle weakness. He described his gait as ‘walking like a drunk’ in the absence of alcohol. H...

Objectives: Prolactinomas can extend out of the sella turcica and invade surrounding structures and the brain. The prevalence and natural history of epilepsy at presentation of macroprolactinoma is not clear.Methods: The case records of 62 patients (34 male) with macroprolactinoma attending a neuroendocrine clinic were studied.Results: Four patients (6.5%, 3 males) had experienced epileptic seizures before the diagnosis of macropro...

Common non-specific symptoms like fatigue can occasionally point towards a rare significant pathology. We report a similar case in which investigations for subtle symptoms revealed a serious unexpected diagnosis. A 76 year-old man presented to his GP for new onset mild fatigue. He had an underlying prostate cancer with no known metastases, treated only with hormonal therapy. This was under surveillance with urology team. GP sent off blood tests which showed a very low random s...

A pituitary hormonal profile and MRI pituitary was requested revealing eupituitary hormonal status with an incidental finding of 4 mm microadenoma. The case was discussed in local MDT and the outcome was to continue conservative management of PHPTH with cinacalcet until pheochromocytoma has been ruled out completely. Both MEN-1 and MEN-2 are associated with PHPTH. If a patient is having episodic adrenergic crises with inconclusive metanephrines analysis then excluding pheochro...

Background of Study: Polycystic ovarian syndrome (PCOS) is an endocrine disorder, contributing to increased neurodegenerative disorders including hypothalamic disturbance. Short chain fatty acid (SCFA) has been reported to regulate metabolic health. However, its therapeutic nature in hypothalamic dysfunction, especially in PCOS individuals is unknown. This study hypothesized that SCFA reverses hypothalamic injury and its related abnormalities in experimentally...

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 has led to unparalleled burden on national and global healthcare systems. Vaccines were viewed as way of combating Covid 19 pandemic. This led to development and implementation of vaccination programmes worldwide. Several vaccines have been approved for use in worldwide including Pfizer-BioNTech, Oxford-AstraZeneca vaccine and Moderna vaccine. Disturbingly, the speed at which these va...

Introduction: Development and progression of cancers is multifactorial encompassing several mechanisms that aid its proliferation. One of the hallmarks of cancer progression is inhibition of the immune system. Cancer cells can activate different immune checkpoint are pathways that harbour inhibitory or stimulatory mechanisms that enabled self-tolerance and assist with immune response. Through activation of immune checkpoint pathways cancers can suppress immune response against...