Endocrine Abstracts

Introduction: It was shown that a relationship between uric acid and cardiovascular diseases, and hyperuricemia is associated with systemic inflammation. But, determination of uric acid is widely available and inexpensive, it has been overlooked as a marker of systemic inflammation and metabolic disturbances. In this study, we aimed to evaluate uric acid value and its association with inflammation and metabolic disturbances in overweight and obese Turkish women.<p class="a...

Aim: Increased levels of fasting parathyroid hormone(PTH) have been hypothesized to influence increased levels of body fat mass. Preliminary studies show that serum PTH levels are higher in obese than in non-obese young adults and decline with weight loss. In the present study, it was aimed to evaluate relationship between antropometric and metabolic risk parameters and PTH levels in Turkish women.Materials and methods: Analyses were performed on 710 Tur...

Introduction: Age at menarche reflects various health aspects including the timing of sexual maturation, growth and nutritional status, and enviromental conditions. This study carried out assesment obesity risk and the relationship between obesity, metabolic parameters and age at menarche in a series of Turkish women.Materials and methods: In a survey of obesity outpatient clinic, 4212 women who have mean age 38.5±12.1 years and ages at menarche bet...

Homozygous familial hypercholesterolemia (HoFH) represents a potentially fatal condition that is caused by low density lipoprotein (LDL) cholesterol receptor deficiency. Statins alone are not effective in HoFH. In recent years, semiselective or selective LDL cholesterol apheresis systems have been shown to prolong life. However, applying LDLC apheresis therapy, recent evidence also suggests that more intense LDL cholesterol reduction is associated with more clinical benefit. E...

C-reactive protein (CRP) is a non-specific but sensitive marker of underlying systemic inflammation. High CRP levels correlate with risk for future cardiovascular events. Statins can lower the circulating levels of CRP. In contrast, the evidence that fibrates lower CRP levels is very limited. This retrospective study evaluates the effect of micronised fenofibrate on plasma levels of CRP in patients with combined hyperlipidemia.Sixty-four patients with co...

Numerous clinical manifestations have been described in association with Cushing’s disease (CD). There was no eligible data on pulmonary function tests in CD patients. We aimed to assess pulmonary function test included spirometry in a series of patients with active Cushing’s disease (2 men, 9 women). Mean age, height, weight, body mass index were 36.7±12.6 (range 22–63 years), 156.9±8.4 cm, 74.1±10.7 kg, 29.6±3.8 kg/m2, respective...

Objective: Patients with hyperthyroidism occasionally need rapid restoration to the euthyroid state. In wiew of the increased enterohepatic circulation of thyroxine (T4) and triiodothyronine (T3) in thyrotoxicosis, and metabolic effects of konjac glucomannan in gastrointestinal system, we aimed to determine the activity of glucomannan in treatment of hyperthyroidism.Methods: A prospective, randomized, placebo-controlled, one-blind study design was used w...

Aim: Pregnancy and pheochromocytoma are an important clinical picture in which the mother and fetus are under threat. Herein, we present a case diagnosed with pheochromocytoma in the follow-up of fetal mortality and maternal pulmonary edema after emergency postnatal caesarean section.Case Report: Our case was a 32-year-old female, fetal distress was determined after hypertension and maternal hypoxemia in 26 weeks of gestation and emergency caesarean sect...

Hashimoto’s thyroiditis is thought to result from the decreased of T helper type 2 (Th2) responses, leading to progressive destruction of thyrocytes. IFN-λ1, -λ2, and -λ3 (also known as IL-29, IL-28A, and IL-28B, respectively) is a recently described member of the IFN-λ family and has been shown to decrease production of Th2 cytokines in vitro. However, the role and mechanism of IFN-λ1 in Hashimoto’s thyroiditis remain unkno...

Aim: To evaluate serum (SMK) and nodular (NMK) midkine levels in thyroid nodules and explore its relevance to ultrasound feature/pathological results.Methods: A total of 80 patients (56 women, 24 men) with thyroid nodules were included in this prospective study. Hemograms, thyroid function tests, fine needle aspiration biopsies, ultrasonographic evaluation were routinely made. In addition, levels of SMK and NMK were measured. Any possible correlations be...