Endocrine Abstracts

Objective: We studied a previously uncharacterized poly A(−) RNA transcript (designated Heg) in blood mononuclear cells and its relationship to TSH receptor autoantibodies and to CD14, Nucks, Cdk1, GCRα, NF-κB and CK2 mRNA.Subjects and methods: The main study groups were a) normal subjects b) patients with early and untreated Graves’ disease and c) patients with Graves’ disease studied after treatment. Quantification of mRNA was...

Background: High oxidative stress is associated with increased morbidity. The effect of testosterone treatment (TT) on oxidative stress in ageing men with reduced bioavailable testosterone is undetermined.Aim: To determine the effect of TT compared to placebo on oxidative stress biomarkers.Methods: Double-blinded, placebo-controlled study in 38 men, aged 60–78 years, with bioavailable testosterone <7.3 nmol/l and waist cir...

Objective: To determine the cumulative incidence of nonadherent patients with type-2-diabetes from an outpatient clinic, and to examine determinants and consequences of premature discharge.Research design and methods: A cohort comprising patients with type-2-diabetes referred to a Diabetes Clinic from 2009-2012 was assessed. Patients were categorized as nonadherent if discharged within two years of referral due to nonattendance and/or nonadherence to med...

Background: Cardiorespiratory fitness is a measure for physical activity and a prognostic health indicator. However, measurement of maximal oxygen consumption (VO2max) is not possible in clinical practice.Aim: We hypothesized that body composition and testosterone levels could be used as possible determinants of VO2max in young men.Participants and design: The Odense Androgen Study, a population-based, observational study including...

Introduction: Hyperthyroidism has been suggested to adversely affect cognitive function. However, this association could also be caused by genetic and environmental factors affecting both the development of hyperthyroidism and cognitive functioning. By investigating cognitive function within twin pairs discordant for hyperthyroidism, this potential confounding can be minimized. The aim of this study was to examine if hyperthyroidism is associated with long-term cognitive dysfu...

Background: Hyperthyroidism has been associated with increased all-cause mortality. Whether the underlying cause of hyperthyroidism influences this association is unclear. Our hypothesis was that Graves’ disease (GD) and toxic nodular goiter (TNG) differ with respect to mortality risk and cause of death.Methods: An observational cohort study, using record-linkage data from nation-wide Danish health registers. 1.291 and 861 subjects with GD and TNG, ...

Background: Hypothyroidism has been linked with an increased risk of morbidity such as cardiovascular disease and diabetes mellitus. However, it is unknown whether the burden of morbidity is present before or after the diagnosis of hypothyroidism.Aim: Evaluate the temporality and type of morbidity in hypothyroid patients.Methods: Observational cohort study. Based on record-linking between official Danish health registers 2822 subje...

Introduction: Overt hyperthyroidism (OH) is associated with potentially lethal conditions such as atrial fibrillation, pulmonary embolism, stroke and coagulopathy. OH has also been connected with an increased mortality. However, this could be the result of common genetic and environmental factors affecting both OH and mortality.Objective: To investigate if OH is associated with an increased mortality and to what degree the relation might be explained fro...

Background: Overt hypothyroidism (OH) has repeatedly been associated with a number of potential lethal conditions. However, it is still debated whether OH is linked with increased mortality. Moreover, a link between OH and mortality could be the result of common genetic and environmental factors affecting both OH and mortality. Investigating twin pairs discordant for OH can minimize this potential confounding. Our objective was to investigate, at a nationwide level, whether OH...

Introduction: Vitamin D insufficiency is common in subjects with type 2 diabetes. Observational studies suggest that vitamin D plays a role in the pathogenesis of type 2 diabetes. However, results of intervention studies have been inconsistent. We investigated the effects of improving vitamin D status on insulin sensitivity and inflammatory markers in type 2 diabetic patients with vitamin D insufficiency.Methods: A double blind, randomized, placebo contr...