Endocrine Abstracts

The cell-cell interactions that occur within the breast tumor microenvironment are critical determinants of cancer cell fate. In the face of treatment, the theory of clonal evolution dominates current thinking. Thus, individual cells may acquire a mutation(s) that provides a selection advantage, i.e., Darwinian selection acts at the single cell level. We studied the effect of antiestrogen treatment on the population remodeling ...

The cell-cell interactions that occur within the breast tumor microenvironment are critical determinants of cancer cell fate. In the face of treatment, the theory of clonal evolution dominates current thinking. Thus, individual cells may acquire a mutation(s) that provides a selection advantage, i.e., Darwinian selection acts at the single cell level. We studied the effect of antiestrogen treatment on the population remodeling ...

Background: The highest rates of childhood obesity are among children from lower socioeconomic groups. Tier 3 weight management services for children currently rely on an MDT approach that is focused on the management of complications associated with excessive weight, but the resources are generally limited. Evidence suggests that the input in the community is key to empower children, young people, and their families to make healthy lifestyle changes, although the availability...

Introduction: Evaluating hunger and hyperphagia is an important component of assessing children and young people with obesity. Identifying increased hunger levels will help clinicians and health professionals to taper management aspects including relevant genetic testing and providing tailored dietary and pharmacological management.Aim: The aim of this study was to evaluate the baseline hunger levels in a group of UK adolescents with severe obesity.<...

Introduction: Visceral body fat has been shown to correlate with complications related to obesity. Body mass index (BMI) is widely used to define obesity in the adolescent population; however, it does not take the overall body composition into account. We present body composition data in a group of UK adolescents attending the tertiary MDT weight management service.Methods: Data was collected on 31 patients (M:F = 15:16) attending the MDT service over a ...

Introduction: Childhood obesity is associated with several complications related to physical and mental health. Determining health-related quality of life (HRQOL) is an important outcome measure to ensure patients receive the appropriate care.Aim: We report the baseline HRQOL in a group of UK children and adolescents with severe obesity who were managed in a Tier 3 weight management service.Methods: Paediatric quality of life (Peds...

Post-prandial hypoglycaemia (PPH) can be associated with debilitating symptoms. Causes include altered physiology post-bariatric and upper gastrointestinal (GI) surgery and rarely noninsulinoma pancreatogenous hypoglycemia syndrome and insulin antibodies. We present a case of 49y female with no prior GI surgery presenting with debilitating hypoglycaemia with blood glucose falling to 2.8 mmol/l responding to glucose. Freestyle Libre monitoring confirmed hypoglycaemia 2-3 h post...

Secondary hormonal deficiency (SHD) in sellar masses (SM) is thought to be partly due to compression of the portal vessels by the enlarging tumour restricting the blood supply to the normal pituitary tissue. However, to date no study has looked at the patterns of SHD in various types of SM and assessed if SHD is related solely to the size of SM or is associated with the underlying pathology. We assessed 914 patients with SM enrolled in our comprehensive pituitary registry sinc...

Patients with sellar masses (SM) undergoing transsphenoidal surgery (TSS) have a significant risk of transient or permanent endocrine dysfunction; therefore, in-hospital endocrinology consultation (IHEC) is recommended for these patients. However, routine assessment of all TSS patients by a specialized team is not feasible outside select centers. We developed an IHEC guide for TSS patients in December 2015 to identify those patients who would require perioperative IHEC. We con...

Olfactory neuroblastoma (ONB) is a rare neuroendocrine tumour arising within the sino-nasal cavity. It occurs world wide, affecting both sexes, all ages and all races with no underlying predilection having yet been identified. ONB exhibits a range of phenotypes from indolent to very aggressive, and up to 5% cases are associated with ectopic hormone secretion. Despite current gold-standard treatment of surgical resection (either endoscopic or craniofacial resection) followed by...