Endocrine Abstracts

Endocrine-Related Cancer 2016 23 839–856. DOI: 10.1530/ERC-16-0359...

Background: IVF is an effective treatment for infertility, however it may be complicated by the potentially life-threatening ‘ovarian hyperstimulation syndrome’ (OHSS). OHSS is an iatrogenic condition, resultant on the mode of triggering oocyte maturation. Kisspeptin safely triggers oocyte maturation in women at high risk of OHSS, but has yet to be compared with current triggers of oocyte maturation (hCG or GnRH agonist).Meth...

Background: IVF is an effective treatment for infertility, however it may be complicated by the potentially life-threatening ‘ovarian hyperstimulation syndrome’ (OHSS). OHSS is an iatrogenic condition, resultant on the mode of triggering oocyte maturation. Kisspeptin safely triggers oocyte maturation in women at high risk of OHSS, but has yet to be compared with current triggers of oocyte maturation (hCG or GnRH agonist).Meth...

Background: In women, androgen excess is associated with an increased risk of non-alcoholic fatty liver disease (NAFLD). Androgen precursors are released from the adrenal gland and converted to active androgens in peripheral tissues including adipose tissue. Although the liver plays a key role in all metabolic processes in the body, its involvement in androgen metabolism is yet to be explored. Here, we describe the investigation of androgen metabolism in human liver using norm...

Secondary hormonal deficiency (SHD) is common in patients presenting with nonfunctioning pituitary adenomas (NFA). NFA can either stain for various hormones or be non-hormone staining on immunocytochemistry. To date, no study has assessed the association between staining pattern of NFA and pattern of SHD at presentation. The Halifax Neuropituitary Program has been prospectively collecting comprehensive data on all neuropituitary patients in the province of Nova Scotia, Canada ...

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy of reproductive age women and is characterized by reproductive, metabolic and psychological features exacerbated by weight gain. Weight management in PCOS is challenged by propensity to weight gain and lack of sustainable dietary interventions. Body weight is regulated by calorie intake and the rate of energy expenditure. Metabolically active brown adipose tissue (BAT), contributing to energy dissipation, has b...

Background: Anti-Müllerian Hormone (AMH) and Antral Follicle Count (AFC) are both principally used as markers of ovarian reserve and available in all UK hospitals. The utility of these markers in the binary diagnosis of Polycystic Ovarian Syndrome (PCOS) by published criteria, such as Rotterdam, has been previously reported. We evaluated their utility in the evaluation of oligo/amenorrhoea in healthy young non-obese women.Methods: Women with both ov...

PTH promotes conversion of 25-hydroxyvitamin D (25[OH]D) to 1,25-dihydroxyvitamin D (1,25[OH]2D), thus stimulating intestinal calcium and phosphate absorption. Because of low PTH levels in hypoparathyroidism, patients are prescribed calcitriol. Patients are predisposed to hyperphosphatemia owing to loss of PTH-stimulated phosphate excretion by the kidneys. Effects of rhPTH(1–84) on vitamin D metabolism and serum phosphate were studied.In ...

Introduction: Giant cystic phaeochromocytomas are an exceedingly rare variant of adrenal phaeochromocytomas. We report a case in an 83-year-old lady who initially presented with a swinging pyrexia, initially diagnosed as a hepatic abscess.Case report: An 83-year-old lady with a history of hypertension was admitted as an emergency with nausea and vomiting, dehydration and rigors. She was pyrexial and dehydrated; pulse 163 and BP 167/86. There were signs o...

NHS England has established several Complications from Excess Weight (CEW) services. Despite physical activity (PA) being an integral part of successful weight management programmes, the capacity to offer an effective PA program within CEW services could be limited by resources. The aim of the study was to assess the feasibility of embedding an exercise specialist led, mobile health (mHealth) technology supported, PA and exercise intervention (MOTIVATE-CEW) to a CEW service. A...