Endocrine Abstracts

Background: Kisspeptin is a novel hypothalamic hormone with powerful stimulatory effects on the hypothalamo-pituitary–gonadal (HPG) axis. Inactivating mutations in the kisspeptin receptor lead to pubertal failure. We have previously demonstrated that injection of kisspeptin-54 stimulates LH release in healthy men and women. Recent studies in animals suggest that endogenous kisspeptin may be involved in stimulating the GnRH pulse generator. Determining whether exogenous ad...

Kisspeptin, encoded by the KiSS-1 gene activates the G protein coupled receptor 54 (GPR54). The kisspeptin/GPR54 system plays an essential role regulating reproductive development. The human placenta has a high expression of both the KiSS-1 and GPR54 genes. Plasma kisspeptin levels increase several thousand fold in pregnancy. The physiological role of kisspeptin in pregnancy is not clear. Kisspeptin causes vasoconstriction during in vitro studies and may play a r...

Kisspeptin, the endogenous ligand of the GPR54 receptor, is a key regulator of the hypothalamo-pituitary-gonadal (HPG) axis. GPR54-null mice exhibit reproductive dysfunction and exogenous kisspeptin potently stimulates the HPG axis in rodents, primates and human males. The effects of kisspeptin administration to human females are not known.Aim: To investigate the effects of kisspeptin on luteinising hormone (LH) release during the menstrual cycle in fema...

The rise in the prevalence of obesity has imparted urgency to the study of the mechanisms of appetite regulation. Oxyntomodulin (OXM) and glucagon-like peptide-1 (GLP-1) are anorexigenic gut hormones thought to act via the same receptor. There is an increasing body of evidence, however, that they may act via distinct pathways. Magnetic resonance imaging (MRI) is increasingly being used as a tool for tracking changes in neuronal activity in vivo through time. Manganese-e...

(This poster is based on OC17)...

Mutation of the GPR54 receptor is associated with a failure of reproductive function. The endogenous neuropeptide agonist for GPR54, kisspeptin, potently stimulates the hypothalamic-pituitary-gonadal (HPG) axis in rodents and primates.Objective: The present study was designed to determine the effects of elevating circulating kisspeptin levels on LH, FSH and testosterone in male volunteers.Method: Study (i) Volunteers were infused w...

Kisspeptin is a 54 amino acid peptide, encoded by the anti-metastasis gene KiSS-1, that activates the G-protein-coupled receptor, GPR54. The kisspeptin/GPR54 system is critical to normal reproductive development. KiSS-1 gene expression is increased in the human placenta in normal and molar pregnancies. Circulating kisspeptin is dramatically increased in normal pregnancy but levels in gestational trophoblastic neoplasia (GTN) have not previously been reported. The...

Background: Infertility is a common problem and the number of couples receiving assisted reproductive treatment (ART) is increasing. Using GnRH agonists (GnRHa) to trigger oocyte maturation has been shown to reduce risk of ovarian hyperstimulation syndrome (OHSS), a common complication of IVF, compared to the more traditional use of human chorionic gonadotropin (hCG). Kisspeptin has recently been shown to be a safe trigger of oocyte maturation in women at high risk of OHSS. Ki...

Background: Millions of men worldwide take anabolic-androgenic steroids (AAS) to boost muscle growth, but risk psychosis, cardiomyopathy, stroke and death. Users avoid stopping AAS because they are fearful of low testosterone symptoms including sexual dysfunction, depression and suicidality. To avoid these symptoms, men often illicitly self-medicate a 2–12-week course of drugs including selective oestrogen receptor modulators to boost testicular function ...

Menopause management guidelines advocate a personalised, evidence-based approach to menopause-care. This study explored the current landscape of menopause-care, from both patients’ and healthcare-providers’ perspectives, to better understand barriers to menopause-care across the UK.Methods: A 25-question online patient-survey and a 23-question GP-survey was designed with individuals with lived-experience of menopause to underst...