Endocrine Abstracts

Prostate cancer (PCa) patients are typically treated by androgen ablation therapies that ultimately fail when PCa enters in androgen-depletion independence (ADI), leading to metastasis and death. To develop better clinical treatments it is crucial to understand the mechanisms underlying progression towards ADI and metastasis. Using ChIP-seq technology, I will show how the forkhead factor FoxA1 precisely restricts the extension of the androgen receptor (AR) binding program main...

We report two patients with thyroid nodules where thyroid cancer has unexpectedly been found. The first patient presented at the age of 58 years with a lump in her neck. She was clinically and biochemically euthyroid. Ultrasound revealed a solitary left hypoechoic nodule (23×17 mm), with no other suspicious sonographic features. She had two FNA’s over a two year period which were reported as showing no malignant cells (THY2). Three annual ultrasounds showed no change...

Cytokines, including adhesion molecules, are a family of protein mediators that are important in transducing information between various cell types, were non-immune cells may also be important sources of certain cytokines.Aim: Aim of this study was to evaluate of soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), and soluble E-selectin (sE-selectin) in patients with non-immune nodular thyroid disease...

Aim: To evaluate alterations in plasminogen activator inhibitor-1 (PAI-1), myeloperoxidase (MPO) and matrix metalloproteinase-9 (MMP-9) levels, and their relation to insulin resistance (IR) in coronary artery disease (CAD) patients with stable and unstable angina with and without type-2 diabetes mellitus (T2DM).Patients and methods: CAD patients were recruited into four groups: 16 CAD patients with stable angina and T2DM (SD); 16 CAD patients with stable...

Aim: To evaluate relationships between adipokines (adiponectin, resistin, leptin, interleukin-6, tumor necrosis factor-alpha), insulin resistance and cutaneous vasomotor responses in metabolic syndrome (MS) patients with insulin resistance. MS patients with insulin resistance were divided into two groups: 18 patients with type-2 diabetes mellitus (without insulin therapy and pronounced diabetic complications) (DM) and 18 patients without DM. Of 18 healthy subjects were selecte...

Objective: To describe the clinical presentation of forefoot and midfoot diabetic foot ulcers (DFUs) complicated by osteomyelitis and their outcomes with conservative management in a multi-disciplinary care environment and determine predictors of ulcer healing.Methods: This is a retrospective study of all consecutive cases of DFUs complicated by osteomyelitis presenting to our multi-disciplinary diabetes foot clinic between 1st January and 30th June 2016...

Early detection, surgery and targeted treatments have seen remarkable improvements in cancer survival. Yet for many patients, cancers still relapse in distant organs after seemingly successful treatment of primary disease. The skeleton is one of the most common sites. Multiple myeloma develops directly in bone, whereas solid tumours, including breast and prostate cancers, spread to bone, often early in the clinical course, giving rise to incurable disease. It remains unclear h...

In humans and other mammalian species, the pool of resting primordial follicles serves as the source of developing follicles and fertilizable ova for the entire length of female reproductive life. In recent years, molecular mechanisms underlying follicular activation have become more evident, mainly through the use of genetically-modified mouse models. As hypothesized in the 1990s, the pool of primordial follicles is now known to be maintained in a dormant state by various for...

The adrenal cortex is a dynamic organ that undergoes self-renewal. In the mouse it is divided into two concentric layers, the outer zona glomerulosa (ZG) and the inner zona fasciculata (ZF), that secrete aldosterone and corticosterone, respectively. Capsular and subcapsular stem/progenitor cells differentiate and migrate in a centripetal fashion to repopulate the gland until they reach the juxtamedullary region where they undergo senescence and apoptosis. Cell fate mapping stu...

The adrenal cortex is a dynamic organ that undergoes self-renewal. In the mouse it is divided into two concentric layers, the outer zona glomerulosa (ZG) and the inner zona fasciculata (ZF), that secrete aldosterone and corticosterone, respectively. Capsular and subcapsular stem/progenitor cells differentiate and migrate in a centripetal fashion to repopulate the gland until they reach the juxtamedullary region where they undergo senescence and apoptosis. Our lab has previousl...