Endocrine Abstracts

Introduction: Besides medullary thyroid carcinoma (MTC), increased calcitonin serum concentrations may be due, rarely, to neuroendocrine tumour (NET) ectopic secretion, especially those of the foregut (pancreatic/lung). Patients with NETs and right-sided heart failure due to cardiac carcinoid have a worse prognosis than those presenting without. Case presentation: We present the case of a 72-year-old female with a history of an initially considered well-...

Introduction: Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy. It represents over 80% of all follicular derived well-differentiated thyroid cancers. Despite the fact that the majority of PTCs are well differentiated and have a low rate of local invasion, recurrences, or metastases, there are complex cases which require a multidisciplinary team for a favourable result.Methods: Clinical examination, blood tests, scintigraphy, CT s...

Background: Dopamine agonists (DA) have excellent result in controlling both hyperprolactinemia and tumor volume in macroprolactinomas. However, even after long term DA treatment, withdrawal of dopamine agonists results in recurrence of hyperprolactinemia in a significant proportion of patients.Aim: To assess recurrence rate of hyperprolactinemia after DA withdrawal in a large series of patients treated in a tertiar...

Introduction: Pituitary adenomas are the most common pituitary tumours, but in 18% of cases we can find other rare tumours like: Rathke’s cleft cyst, craniopharingyomas, chordomas, meningiomas, infiltrative or infectious disease. Meningeal melanocytoma is a benign neoplasm of central nervous system, commonly located in the base of the brain, cerebellopontine angle and the pineal body, difficult to differentiate from a nonfunctional p...

Background: Dopamine agonists (DA) have excellent result in controlling both hyperprolactinemia and tumor volume in macroprolactinomas. However, even after long term DA treatment, withdrawal of dopamine agonists results in recurrence of hyperprolactinemia in a significant proportion of patients.Aim: To assess recurrence rate of hyperprolactinemia after DA withdrawal in a large series of patients treated in a tertiar...

Introduction: Pituitary adenomas are the most common pituitary tumours, but in 18% of cases we can find other rare tumours like: Rathke’s cleft cyst, craniopharingyomas, chordomas, meningiomas, infiltrative or infectious disease. Meningeal melanocytoma is a benign neoplasm of central nervous system, commonly located in the base of the brain, cerebellopontine angle and the pineal body, difficult to differentiate from a nonfunctional p...

Congenital hypopituitarism is a rare disease, occurring sporadically in the vast majority of cases, that is found more frequently in males. We are presenting the case of a 19 year old that addressed our clinic because of short stature and lack of development of secondary sexual traits. During the clinical assessment we found his height to be 146 cm, corresponding to -4.78 SDs, Tanner stage of pubertal development 1 and lack of apocrine axillary odor. The patient was inapetent ...

Background: PA is a frequent cause (5–13%) of secondary hypertension (HT), yet diagnostic work-up of PA remains challenging.Aim: To describe the characteristics of hypertensive patients diagnosed with PA, biochemical screening (aldosterone:renin ratio/ARR), confirmatory tests, and adrenal CT results.Methods: Clinical, hormonal and imaging evaluation.Results: 13 patients (7M/6F) with PA were 45 yrs (40&#1...

Background: Dopamine agonists (DA) are the first-line treatment for macroprolactinomas. However, up to 10% of patients fail to respond to medical therapy.Aim: To assess biochemical resistance rate to DA treatment in a large series of patients with macroprolactinoma and to analyze possibilities to overcome this resistance.Patients and methods: 195 patients with macroprolactinomas, treated with DA for at least 2 years, were retrospec...

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is a rare, autosomal dominant inherited syndrome caused by mutations in the MEN1 tumor suppressor gene and is characterized by the occurrence of parathyroid, pancreatic islet and anterior pituitary tumors. We present the case of a female patient known to have pituitary and parathyroid tumors in a MEN1 syndrome evolving for more than 20 years before associating pancreatic neuroendocrine tumor.Case r...