Endocrine Abstracts

Introduction: Severe hyperandrogenism is not only associated with cosmetic concerns but it also increases the risk of neoplastic (endometrial, breast cancer), cardiovascular, respiratory and metabolic complications.Case report: A 68 years-old woman with a recent history of severe arterial hypertension, cardiogenic pulmonary edema, diabetes mellitus, severe respiratory failure, marked obesity was referred to our department due to the markedly androgenic p...

Introduction: Ectopic thyroid tissue (ETT) is a rare entity; it is more frequent in women (80%) and is usually located along the obliterated thyroglossal duct. ETT in the midline is even rarer (1.79%). Incidence of malignancy in this group is lower than in orthotopic thyroid nodules.Case report: A 40 years old woman, resident in iodine sufficient area, but originating from an iodine deficient area, presented for a midline neck mass. TSH and FT4 were meas...

Introduction: Accessory thyroid tissue is a part of thyroid dysgenesis and sometime represents an incidental adult finding displaying a normal function.Material and Methods: This is a case presentation of an adult admitted for an atypical anterior cervical aspect which could not be recognized as accessory thyroid tissue only after surgery. Thyroid evaluation used imagery like ultrasound, computed tomography (CT), assays as TSH (Thyroid Stimulating Hormon...

Introduction: Synovial sarcoma represents a type of cancer derived from soft tissues; young males are more affected.Material and methods: This is a case report of a male with a cervical mass confirmed as sarcoma. Later on the investigations lead to the discovery of a thyroid nodule challenging the differential diagnosis. We assessed thyroid ultrasound, computed tomography (CT) at the cervical, thorax, mediastinum and abdomen; TSH (Thyroid Stimulating Hor...

MEN2A is an autosomal dominant inherited syndrome, caused by a gain of function germline mutation in the RET proto-oncogene, with multiglandular tumoral development. Although the presence of MTC is very high and 50% of patients present with pheochromocytoma, the penetrance of hyperparathyroidism is estimated to be between 9 and 34%. The clinical presentation of the syndrome varies widely even in members of the same family, because of the difference of gene penetration (1). In ...

Acromegaly control/remission is defined by stringent criteria: normal age-/sex-adjusted IGF1 and random GH (GHr) <1 ng/ml or a GH nadir (GHn) during oral glucose tolerance test (OGTT) of <0.4 ng/ml. However discordances between GH and IGF1 have been recorded in about 30% of patients. We retrospectively analyzed the evolution in patients with acromegaly and discordant GH–IGF1 levels while being treated with somatostatin analogs (SSA) and/or cabergoline (CAB).<p...

Introduction: Pheochromocytomas are rarely malignant, defined by the presence of cathecholamine – producing metastases. Malignant pheochromocytoma responds poorly to chemotherapy and radiotherapy. 131I-MIBG therapy can be used to prolong survival, with minor side effects.Case: A 45-years old woman known with malignant pheochromocytoma, with a long medical history, first came to our clinic in July 2012. Her diagnosis was suspected in 1999 ...

Introduction: The pituitary non-secreting microadenomas (or incidentalomas) are frequently diagnosed over the last decades thanks to imagery scan progresses and access. The gonadal dysfunction, as well as other pituitary deficiency is related to common genetic backup (+/− other pituitary dysfunctions) or may be incidental.Aim: We analyzed the endocrine profile in pituitary incidentalomas (microadenomas).Material and method: A...

Introduction: The pituitary tumors which are considered pituitary incidentalomas are accidentally discovered at pituitary scan and they associate a lack of pituitary hyper-secretion. Opposite to what generally are considered for adrenal incidentalomas, the pituitary incidentalomas are more frequent with years of life.Aim: We analyzed the incidentaloma sizes related to decades of age.Material and method: This is a retrospective stud...

Introduction: Pituitary tumours may interfere with fertility and pregnancy may be uncommon in these cases, but some patients can conceive spontaneous. Also in pregnancy, due to the physiologic changes of the pituitary gland, gradual volume increase and cellular hyperplasia that target hormonal secretion, the evaluation of the pituitary function is very complex.Clinical cases: We present 5 cases of female patients (24 – 35 years old) that were diagn...