Endocrine Abstracts

AbstractThyroid angiosarcoma is an aggressive and very rare type of thyroid malignancy originally diagnosed in iodine-deficient areas. The prognosis is poor and in most cases surgery proved to be inefficient. The fine needle aspiration biopsy (FNAB) and histology can rarely differentiate angiosarcoma from anaplastic carcinoma, and the final diagnosis is based on immunopositivity for vascular markers and absence of epithelial markers. We present he...

Introduction: Despite the presence of antinuclear (ANA) and anti DNA antibodies in Graves’ disease, the association with Systemic Lupus Erythematosus (SLE) is rare. Responsible for this association seem to be mutations in the PTPN22 gene.Case Report: We report a case of a 27-year-old woman, who presented in January 2009 in our department, at 6 months postpartum, after extensive investigations for autoimmune disease. She had negative results for poly...

Introduction: Remission rate in microprolactinomas after treatment with dopamine agonists (DA) is variable, from about 25% in bromocriptine-treated patients to 46% in those treated with cabergoline.Patients: We retrospectively studied the remission rate in 98 patients with prolactinomas ≤1 cm evaluated in 1982–2009 in our department and treated with DA for at least 1 year.Results: Mean age of patients is 26.5±8 year...

Objective: CT findings indicating that a patient is at risk for developing optic neuropathy are worth- while observations.Aim: The aim of our study was to determine the utility of CT imaging in identifying patients at risk for optic neuropathy and to compare quantifiable nonvolumetric CT data from a large series of orbits with Graves ophthalmopathy.Method: A total of 226 patients (452 orbits), 175 women (350 orbits) and 51 men (102...

Introduction: Congenital adrenal hyperplasia is a group of autosomal recessive diseases, caused by mutations in the enzymes implicated in the synthesis of cortisol. In females, the classical pattern is characterized by progressive virilisation, short stature and in severe cases, by salt wasting in the newborn.Results: We present the case of a 14 years old female patient, who was referred to our clinic for primary amenorrhea. Her personal and family histo...

Objectives: Pituitary adenomas usually do not over-secrete gonadotropins in the bloodstream, although they may stain for gonadotropins. Our study aimed to assess whether the pre-operative gonadotropin level in CSF could be used as a marker of the pituitary tumour’s gonadotropin secretion.Patients and methods: 359 patients with pituitary adenomas, diagnosed between 1979 and 2005 in the Institute of Endocrinology, Bucharest, were evaluated before pitu...

Background: There is a large agreement that most of the incidentally discovered, clinically mute adrenal masses are incidentalomas - non-functioning tumours, which have to be explored in order to differentiate the adrenal carcinoma.Material and methods: We studied the prevalence and characteristics of clinically mute adrenal tumours and the evolution of adrenal incidentalomas, with the approval of the local Ethical Committee, in 123 patients with adrenal...

IntroductionOncocytic neoplasms arising in adrenal tissue are extremely rare with nearly 150 cases being reported in literature. They are mostly nonfunctioning benign tumors, incidentally discovered, but 20% of them demonstrate elements of malignancy and up to 30% appear to affect hormone production.Case reportA 35 years old female with primary amenorrhea, diagnosed with Congenital Adrenal Hyperplasia due to ...

IntroductionSilent corticotroph adenoma represent an uncommon subtype of nonfunctioning adenoma, immunoreactive for ACTH, without clinical or biochemical evidence of hypercortisolism and unclear pathogenesis. Usually, they present with local mass effect (visual deterioration being the most common) and endocrine dysfunctions. They carry a more aggressive behavior, particularly upon earlier recurrence.Case presentation<p class="a...

BackgroundLymphocytic hypophysitis is an unusual inflammation of the pituitary gland affecting mostly women. Its pathogenesis is still poorly understood and the presentation and clinical course vary largely. Serum prolactin levels may be low, normal, or elevated. Unlike what is observed in clinically nonfunctioning pituitary adenomas, there is not a clear hierarchy of anterior pituitary hormone deficiencies. Hypophysitismay resolve spontaneously, may rel...