Endocrine Abstracts

Polycystic ovary syndrome (PCOS) is a common hormonal, metabolic and reproductive disorder characterized by androgen excess, ovulatory dysfunction and polycystic ovaries. The phenotypic presentation might differ between referral and unselected populations and varies within an individual over time and between individuals of different ethnic and geographic regions. Women with PCOS have increased prevalence of prediabetes and diabetes and have multiple risk factors for cardiometa...

Multiple endocrine neoplasia type 1 (MEN1) is a rare inherited endocrinopathy characterized by tumours of the parathyroid glands, adenohypophyseal and pancreatic tumours. We present a case of a young, 24 years old female patient with a positive familial background for MEN1 (on the fathers’ side of the family). She is one of two sisters with determined heterozigocity of the MEN 1 gene (Exon 2, codon 111). At the age of 12, insulinoma of the head of the pancreas was diagnos...

Couples in developed countries are increasingly delaying child bearing to later in life. While it is well known that female reproductive functions decrease and genetic risks for the offspring increase beyond the age of 35 and seize completely around the age of 50, the influence of risks of paternal age on fertility and offspring are less well known. Indeed, until recently life long fertility was assumed for the male. However, testicular function slowly declines with age and fe...

Serum of infertile males and that of proven fathers (n=717) was analysed for the measurement of sperm concentration, serum LH, FSH and testosterone. Earlier, when classified on the basis of sperm count, 13% males turned out to be azoospermic, 15% oligozoospermic, 0.025% polyzoospermic and 42% normozoospermic in a five year analysis. Oligozoospermic subjects were further classified as mild, moderate and severe oligozoospermic. Hormonal analysis indicated normal levels of LH and...

Ageing is an inevitable biological process that affects all aspects of human physiology including reproductive health. While much attention has been devoted to the age-related decline in female fertility, the impact of ageing on male reproduction is perhaps less well appreciated. This presentation aims to provide a concise overview of the relationship between ageing and sperm health, highlighting key findings and implications. Ageing has a significant impact on sperm health an...

Introduction: Parathyroid tumors are the most common (90%) and usually the first manifestation feature of MEN1 syndrome. The occurrence of anterior pituitary tumors in MEN1 syndrome may range between 10% and 60%. Pituitary involvement includes the initial manifestation of MEN1 syndrome in 10% to 25% of individuals and usually show more aggressive behavior; 20% secrete prolactin, fewer than 10% secrete GH, 5% secrete ACTH, and the remainder appear to ...

Introduction: Recent studies suggest that some patients initially diagnosed with congenital hypogonadotropic hypogonadism (CHH), may evolve towards a combined pituitary hormonal deficiency (CPHD). Heterozygous pathogenic CHD7 variants impair neural cell crest guidance causing CHARGE syndrome and have been associated with abnormal pituitary development/function/structure and isolated CHARGE features, including HH. We aimed to genotype CHD7 and phenotype thoroughly those adult p...

Traumatic thoracic injuries in children and adolescents are rare, but could be connected with others traumas, often with traumatic brain injury (TBI). Based on data in the current literature, approximately 15–20% of TBI patients develop chronic hypopituitarism. Growth hormone (GH) and ACTH deficiency are the most common, followed by gonadotropins and thyroid-stimulating hormone. The greatest challenge associated with endocrine complications in individuals with polytrauma ...

Introduction: Pregnancy is a stress test on maternal thyroid and pregnant women may be more susceptible to thyroid dysfunction. Consequences of this may be harmful for the mother and fetus. Smoking has been associated with alterations in thyroid hormone concentrations, but little knowledge exists on this association in pregnant women.Subjects and methods: The study population is large, prospective population-based Northern Finland Birth Cohort 1986 (n...

Goal: To study the relation between the obesity of children and their parents, and energy intake.Materials and methods: Of 236 households containing 828 population (356 children age 5–25 years, and the rest their parents) were selected from the subjects of ‘Tehran Lipid and Glucose study’ (2006–2008) for this study. Food intake of the subjects was studied using FFQ. In this study, energy intake ≥75 percentile was regarded as &#1...