Endocrine Abstracts

Background: Androgen co-secretion in patients with adrenal Cushing’s syndrome is considered a marker of malignancy. Mixed secretion by benign adrenocortical tumors is rare. We describe a case of a middle aged woman presenting with Cushing’s syndrome and polycythemia.Case report: A 57-year-old lady was referred by the Hematology Service to our Endocrine Clinic for evaluation of an adrenal mass found in an abdominal CT in the course of investigat...

Introduction: Adrenal masses are among the most frequent tumours in humans (ACT). A vast majority of these tumours are benign (ACAs). Only a small subset of adrenal masses are malignant adrenocortical carcinomas (ACCs). Tumour size, tumour weight, hormonal function and pathologic criteria are useful clinicopathological criteria that can result in accurate diagnosis of most ACCs and ACAs.Case report: 31-years-old woman, without relevant previous history. ...

Introduction: Congenital adrenal hyperplasia (CAH) is an inherited recessive disorder of adrenal steroidogenesis, generally caused by total or partial deficiency in 21-hydroxylase, due to deletions or mutations of CYP21 gene. Some studies suggest that the association between CAH and multiple sclerosis (MS) could be nonincidental: a possible MS susceptibility locus is on chromosome 6p21, on which the CYP21 gene is located.We report the c...

Introduction: ACC is a rare tumour with a incidence of 0.7–2.0/per million, more common in women between 40 and 50 years. Can be diagnosis as a incidentaloma or for clinic of abdominal pain and autonomous o hormone secretion symptoms (Cushing syndrome and hirsutism). We present the management of a particular case of hirsutism for ACC.Case report: Sixty four year old woman referring increase hair and a deeper voice for 1 year. As personal antecedents...

Introduction: Androgen excess in women usually is presented as hirsutism and alopecia. Androgens could be expressed from adrenal or ovarian origin.Case reports: Female, 57 years (yrs) old, presented with hirsutism (Ferriman Galwey score, FGS 18), weight gain, type 2 diabetes mellitus (DM2), hypertension, hyperlipidemia and obesity (BMI 38.5 kg/m2). Diagnostic evaluation revealed normal prolactin, SHBG, DHEAS, IGF-1, ACTH, TSH, serum cortisol i...

Introduction: Hyperthecosis ovarian is a type of hyperandrogenism and severe insulin resistance, usually found in postmenopausal women.Case Report: This case is about a 12 year-old girl who came to our hospital because of a rapidly progressive virilization. She had no medical history. For the previous 10 months, she had felt progressive growth of terminal hair in androgen-dependent areas, abundant hair loss, facial acne and voice changes. Axilarche and p...

Hyperandrogenic disorders cause psychological implication in young girls, limiting the quality of life. Salivary cortisol (SalF) testing was proved to be useful in the evaluations of acute stress responses. Aim of this study was to investigate SalF responses to a stressor event in late adolescent females. We selected 165 drug-free females aged 16–19 years from a cross-sectional epidemiological study. Saliva was collected in the morning before and after a stressor event co...

Introduction: Although phenotype D is well recognised in clinical studies about PCOS, there is still a debate if this phenotype should be evaluated as part of PCOS spectrum. The aim of this study was to evaluate usual anthropometric characteristics in PCOS phenotypes.Methodology: We evaluated 365 PCOS women (PCOS: 25.05±6.24 kg/m2; 25.48±5.21 years) diagnosed using ESHRE/ASRM criteria and 125 BMI-matched healthy women (Controls: 25.4...

Introduction: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder of young women and depending on the diagnostic criteria, it affects 6% to 20% of reproductive aged women. PCOS is also the most common cause of hyperandrogenism in young women with the theca cells of the ovary being the source of androgen excess. PCOS is rarely associated with severe hyperandrogenaemia and atypical features such as rapid progression, presence of virilization or very high Testo...

Introduction: Recent studies report the presence of KLK3 in women serum, KLK3 is excreted by Skene glands, it is involved in the production of cervical-vaginal fluid (CVF). Activation of KLK3 is pH depending, it has been hypothesized to have antimicrobial, immuno-regulator activity and vaginal and cervical epithelial desquamation. We intend to verify if KLK3 is present in female serum, in which menstrual cycle phases KLK3 ...