Endocrine Abstracts

Background: The androgen-secreting tumors constitute fewer than 1% of ovarian tumors. Leydig cell tumor is one of the most common of this type of lesion and it is usually benign, small and unilateral.Case report: A 67-year-old women was referred to the Endocrine clinic due to hirsutism (score 22 Ferriman–Gallwey) and male type alopecia with 3 years of evolution and progressive worsening. Biochemically she had high levels of serum testosterone –...

Background: Hirsutism carries with it significant cosmetic and psycho-social issues. Recent research has shown that various spearmint herbal tea preparations have anti-androgenic properties.What is not known are the specific biochemical reductions in androgen levels and also more importantly, the clinical effects – judged both subjectively and objectively – of the use of spearmint tea for patients with Hirsutism due to PCOS (REC approved).<...

In 2002, we introduced metformin as an alternative treatment option of the anti-androgenic contraceptive pill in polycystic ovary syndrome (PCOS). The analysis of our observations is presented here.170 women (age 14–45 y) were diagnosed with PCOS according to the Rotterdam criteria. 88% had acne, 68% hirsutism, 46% irregular menstrual cycles, 39% BMI over 25 kg/m2, 13.5% had apple-type obesity and 4.7% acanthosis nigricans. 104/170 patien...

We present two patients who were originally diagnosed with polycystic ovarian syndrome (PCOS). A 23 year old was referred with deteriorating hirsutism. Her menstrual cycle was reported as entirely regular following the menarche at age 13. Examination revealed her to be obese with a body mass index of 33 and hirsute, with a Ferriman and Gallway score of 19. She had a typical PCOS appearance on trans-vaginal ultrasound scan. Additional investigations in endocrine clinic revealed...

Introduction: Partial 21-hydroxylase deficiency is a genetic autosomal recessive disorder responsible for accumulation of the precursor upstream of the enzyme block, 17-hydroxyprogesterone (17OHP), and excessive androgen production.Observation: A 29-year-old woman consulted for hirsutism with a Ferriman–Gallwey score of 25. There were no signs of Cushing syndrome and no abnormalities of sexual development. The Laboratory results revealed testosteron...

Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine system disorder among women of reproductive age. Although some studies have suggested an association between PCOS and autoimmune thyroiditis, only a few cases indicating association between PCOS and Graves’ disease are reported.Case report: We present a woman aged 29 with Graves' disease certified by suppressed TSH (0.001 mUI/l), high FT4 (6.6 ng/dl) associated with elevated TRAb (...

İntroduction: Polycystic ovary syndrome (PCOS) is associated with risk of cardiovascular disease (CVD). Endocan is potential immunoinflammatory and endothelial dysfunction marker that may be linked to CVD. This study aimed to evaluate the risk of CVD in PCOS patients and to identify the novel biomarker for CVD risk.Material and methods: We analyzed 52 premenopausal women with PCOS and 59 healthy controls. Clinical, biochemical parameters and endoca...

Objective: To investigate the clinical efficacy and safety of the finasteride (5 mg/day) plus flutamide (125 mg/day) combination therapy in unselected women with moderate to severe hirsutism.Patients and methods: Thirty hirsute women were randomly assigned to two treatment groups. Sixteen patients (group 1) were treated with flutamide (125 mg per day) and 14 patients (group 2) were treated with finasteride (5 mg per day) plus flutamide (125 mg per day) f...

Objective: Hirsutism, affects between 5% and 10% of women during reproductive age. Hirsutism associated with normal ovulatory function and normal circulating androgen concentrations is defined as idiopathic hirsutism and little information is available regarding the molecular pathogenesis.Aim: Significance of polymorphisms of the genes involved in androgen/oestrogen biosynthesis (SRD5A2,CYP19) and their expressions inmodulating the susceptibility ...

Hirsutism, defined as excessive male-pattern terminal hair growth in females, affects about 5–10% of the women of reproductive age depending on the population studied and the method used to determine its presence. Hirsutism is the primary clinical diagnostic criterion of hyperandrogenism. Hyperandrogenism can result from increased androgen production and/or increased sensitivity of hair follicles to androgens. The presence of hirsutism in women can lead to significant psy...