Endocrine Abstracts

Insulin autoimmune syndrome (IAS; Hirata syndrome) is a rare cause of hypoglycemia. It seems to be related to specific HLA class II alleles. Rarely, monoclonal antibody acts as an insulin-binding autoantibody: until now 10 cases have been described in association with a myeloproliferative disorder. In June 2015, a 60-year-old patient presented in a local hospital in Mayotte with confusion, sweating and severe hypoglycemia (blood glucose as low as 20 mg/dl). He was suffering of...

Background: Oncocytic neoplasms are rare adrenal tumours usually considered as benign and non-functional. Conversely, in recent large nationwide study from COMETE network over 50% of the oncocytic adrenocortical tumours were diagnosed as carcinoma according to Lin Weiss-Bisceglia-score. However, until now only 11 cases of metastatic oncocytoma were reported in English literature.Case report: A 54-year-old man with history of abdominal pain and weight los...

Introduction: The bone-sparing effect of oestrogen is mediated via oestrogen receptor alpha (ERα), which stimulates transcriptional action through its two activation functions (AF1 and AF2). In addition to these nuclear effects, a fraction of this receptor is targeted to the plasma membrane and triggers membrane initiated steroid signaling (MISS). Whereas, ERα AF1 plays a crucial role in trabecular bone, but not cortical bone, ERα AF2 is necessary for the oestro...

We studied 84 patients with neuropsychological disabilities at least 1 year after TBI. 24 patients had severe GHD (29%). The aim of this study was to evaluate the effects of six months GH treatment on quality of life and metabolism in this group.GH treatment was initiated in 17 patients (71%), planned with 3, declined by one, contra-indicated in 2, 1 patient moved. It lasted more 6 months in 16 of them (14 men, mean age 36±12, mean delay after TBI 7...

Vesicular thyroid tumours evolve from benign to malignant states, respectively called adenomas and carcinomas by respect to the World Health Organisation classification. Borderline cases, atypical adenomas, cannot be clearly classified. When an abnormal cytoplasmic mitochondrial proliferation occurs into the tumour cells, these tumours called oncocytomas, are more aggressive. Oncogenic mechanisms and signal pathways of these tumours are not well known and the origin of the onc...

Pheochromocytomas are catecholamine-producing tumours with diverse cardiovascular and metabolic outcomes including insulin resistance and weight loss. However, impacts on adjacent and distal fat depots are not fully defined and more particularly concerning induction of beige/brown adipose tissue (AT). The aim of the study is to characterize the cellular composition, the metabolic function and the expression of brown AT markers in matched perirenal (PRAT) and abdominal subcutan...

The aims of this study were to determine the prevalence of pituitary dysfunction in patients keeping neuropsychological disabilities long after TBI (at least 1 year), to research predictive factors and to evaluate consequences of endocrine abnormalities on metabolism and quality of life in these patients.We studied 50 patients (42 men, mean age 36, range 20–59 years, mean BMI 25, range 17–42 kg/m2) who had survived severe (n=3...

Recently, several groups have described a subset of obese women, who despite having excessive total body fat, are insulin sensitive (ISO for Insulin Sensitive Obese), normotensive and present a favorable lipid profile. Adiponectin, ghrelin and leptin play important roles in the regulation of energy metabolism and food intake. Moreover, all three hormones have been reported to be closely linked to insulin resistance and regulated by insulin. Therefore, we propose to investigate...