Endocrine Abstracts

Graves’ disease is a common autoimmune condition, and the most common cause of hyperthyroidism. A number of definitive treatment options for this disease exist, including radioiodine (RI) and surgery. Surgery is often reserved for patients for whom RI is contraindicated or who have previously failed other treatments, including radioactive iodine ablation (RIA). The aim of this study was to assess the efficacy and safety of total thyroidectomy at our institution as a pref...

Thyrotoxic periodic paralysis (TPP) is a rare endocrine emergency where early diagnosis of both hypokalaemia and thyrotoxicosis are vital to allow prompt treatment to prevent life-threatening complications and prevent recurrences. We present the first reported case of TPP in which four known stimulants of Na–K–ATPase acted simultaneously to produce profound hypokalaemia. A 32 year-old competitive body-builder took thyroxine supplements & a long-acting β2 ago...

Introduction: Luteinising Hormone Releasing Hormone stimulation test (LHRH) is the gold standard test for diagnosing central precocious puberty (CPP). However, previous studies have advocated using a single LH (Luteinising Hormone) measure to diagnose CPP thus reducing the patient’s investigative burden.Method and aims: We assessed if i) baseline LH levels predicts response on LHRH test ii) the timing of basal LH me...

Obesity is often framed as a consequence of inadequate physical activity, and patients with severe obesity sometimes attribute their weight gain to immobility and reduced exercise. We sought to compare Total Daily Energy Expenditure (TDEE) in adults with severe obesity to what their predicted TDEE would be at their Ideal Body Weight (IBW). We conducted a cross-sectional analysis of the Croí CLANN prospective cohort study of patients with severe obesity attending our regio...

Case history: A 61-year-old gentleman first presented to A&E following a collapse at work. After missing lunch, he became combative towards his colleagues and was found to be hypoglycaemic with capillary blood glucose of 2.5 mmol/l. Symptoms rapidly improved after oral glucose intake. The patient reported similar episodes in the past, usually occurring before meals and mainly if missing or delaying a meal. The patient did not have any past medical history of note, did not ...

17alpha hydroxylase deficiency accounts for less than 1% of all patients diagnosed with congenital adrenal hyperplasia. Almost 100 mutations in the CYP17A1 gene causing 17-hydroxylase/17,20-lyase deficiency (17OHD) have been described (OMIM 609300). CYP17A1 is expressed in both the adrenals and gonads. Hallmarks of 17OHD include hypertension, hypokalaemia, primary amenorrhoea and absence of secondary sexual characteristics. Most patients with 17OHD remain infertile.</...

Introduction: Adolescents with persistent gender dysphoria (GD) receive GnRH analogues to achieve pubertal arrest. It is unclear whether this is adequate to achieve biochemical suppression of gonadotrophin (LH, FSH) and sex hormone production.Methods: Gonadotrophins, testosterone and oestradiol were measured in GD patients (15–18 years) before and after monthly Gonapeptyl treatment (3.75 mg i.m.). Patients administered other analogues and/or cross-s...

Background: The effect of weight loss on hypothalamic function is complex and not fully understood. There is interplay between neuropeptides (leptin, ghrelin) and hypothalamus with the postulated aim of energy conservation and prevention of pregnancy during unfavourable conditions. We present a memorable case.Case: A 35-yr-old lady presented with secondary amenorrhoea of 17 years duration. She attained menarche at age 13. At age 16 her periods became sca...

Introduction: Skin tags (acrochordons) are a recognised feature of insulin resistance, but the extent to which they predict an adverse metabolic profile or the response to lifestyle modification in severely obese adults is not known.Aims: We sought to quantify prospectively differences in anthropometric and metabolic characteristics in severely obese adults with acrochordons vs those without acrochordons, and to determine whether the presence of acrochor...

Aim: In consultation, we check a lot of patients who present with diagnose of FM (fibromyalgia) and chronic fatigue syndrome (CFS). Most of these patients have a underlying diagnosis that causes chronic pain or fatigue. These causes are pathologies not easily detected.Endocrine failure is one of the candidates, with hypofyse dysfunction as a possible candidate.Methods: During 1 year: from October 11, 487 patients presented at the c...