Endocrine Abstracts

Case report: A 56-year old man presented with a 3 month history of painful bilateral gynaecomastia and sexual dysfunction. Investigations revealed hypogonadotrophic hypogonadism with markedly elevated serum E2, but otherwise normal baseline anterior pituitary function. Tumour markers were negative and adrenal androgens and LFTs were normal. Imaging identified a ∼6 cm right adrenal mass. Preoperative workup excluded phaechromocytoma, but identified low-grade, ACTH-indepen...

IntroductionCoronavirus disease (COVID-19) in people with diabetes is associated with a disproportionately worse prognosis. DKA is an acute complication of diabetes with a mortality rate of approximately 0.67%. Little is known about natural history of DKA in the presence of COVID-19 infection. This study aimed to explore the effects of COVID-19 infection on presentation, clinical course and outcome in patients presenting with DKA.M...

Background: Diabetic ketoacidosis (DKA) is an acute endocrine emergency in people with diabetes. Paucity of information prevails over sex- and age-related variations in patients presenting with DKA.Objective: To assess the impact of age and sex in the clinical course, presentation, outcome and management of DKA in people with type 1 (T1DM) and type 2 diabetes (T2DM).Methods: We included all DKA from April 2014 to September 2020 in ...

Objectives: Limited evidence exists studying the impact of ethnicity on diabetic ketoacidosis (DKA). We aimed to study the impact of ethnicity on presentation, management and outcome of DKA in type 1 (T1DM) and type 2 (T2DM) diabetes.Methods: All DKA episodes from April 2014 to September 2020 in a UK tertiary care centre were identified. Data were collected on diabetes type, demographics, biochemical and clinical features on admission, and DKA management...

Objectives: We explored the differences in severity and outcomes of diabetic ketoacidosis (DKA) in people with type 1 (T1DM) and type 2 diabetes (T2DM).Methods: All DKA episodes from April 2014 to September 2020 at a tertiary care centre in the United Kingdom were identified. People admitted with DKA were classified as having T1DM or T2DM based on previously established diagnosis, autoantibody status, and/or phenotypic features. We compared the differenc...

Background: Bone toxicity and more specifically Radiotherapy Related Insufficiency Fractures (RRIFs) are common late effects of pelvic radiotherapy, associated with increased morbidity and reduced quality of life, while their cost to the health system is currently unknown. The mechanisms underlying RRIFs are not well understood. Effective preventive techniques and management pathways need to be developed and validated with robust clinical and health economic analyses. The RadB...

Background: Peptide-based targeted alpha-particle radiotherapy has emerged as a promising approach to cancer treatment. 203Pb/212Pb is the only elementally identical isotope pair for this application. Tyr3-Octreotide (TOC) peptide ligands targeting SSTR2 have been widely investigated preclinically and clinically. [177Lu]DOTATATE was approved by the US FDA to treat patients with gastroenteropancreatic neuroendocrine tumors. However, t...

Background: Somatostatin receptor (SSTR) PET imaging is utilized with increasing frequency in the clinical management of neuroendocrine tumors. Incidental PET-avid CNS lesions are commonly noted and presumed to be meningiomas. However, SSTR PET lacks specificity for meningioma identification. This study aims to clarify the role of SSTR-based imaging for classification of incidental CNS lesionsMethods: Patients who had undergone both Ga-68-DOTATATE PET an...

Introduction: Pancreatic β-cells control glucose homeostasis by secreting insulin in response to high glucose. MiRNAs regulate β-cell function and contribute to β-cell failure in type 2 diabetes. MiR-184 regulates β-cell compensatory expansion during pregnancy and obesity and its expression is reduced by glucose through unknown mechanisms. AMPK is a suggested target of antidiabetic drugs and an important energy sensor. Its β-cell-selective inactivation...

Introduction: Duodenal mucosal resurfacing (DMR) is a novel therapy for T2DM. It involves the hydrothermal ablation of up to 14 cm of the duodenal mucosa through a specially designed endoscopic catheter. The procedure is performed under general anaesthesia, patients are discharged the same day and it does not involve the implantation of a foreign body. Cohort studies have demonstrated that DMR induces meaningful hbA1c reductions of 0.9–1.4% by 3 months that are largely m...