Endocrine Abstracts

Introduction: Research has shown that Type 2 diabetes can be reversed in early stages if diet control is exercised. We present herewith a case of a 13-year old girl with Type 2 diabetes with a background of brain tumour, epilepsy and learning difficulties. Due to wider psychosocial issues the patient was placed in foster care. Adherence to healthy lifestyle principles led to weight loss and subsequent resolution of the Diabetes.Case report: A 5-year-old ...

Children and adolescents with Type 1 Diabetes Mellitus (T1DM) are at increased risk for developing other autoimmune diseases. We are presenting this rare association of tubulo-interstitial nephritis and uveitis (TINU) with severe hypercalcaemia and type 1 DM. 12 years old girl, with Type 1 Diabetes for 5 years presented with 4 months history of weight loss, abdominal pain, nausea, tiredness, anorexia and recurrent hypoglycaemias. Her HbA1c levels was 38 mmol/mol (5.6%). She wa...

Introduction: Cranial Diabetes Insipidus (DI) presenting in children beyond infancy is most commonly associated with sellar/suprasellar tumours and severe traumatic brain injury or haemorrhage. Less frequent causes may be genetic or idiopathic. Exceptional cases may be associated with minor head injury. We present a case of post-concussive head injury with DI, and anterior pituitary hormone deficits.Case: 15 year old malesustained a concussive head injur...

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Background: Cystic fibrosis related diabetes (CFRD), a common complication of CF, contributes to increased morbidity and mortality and is a poor prognostic indicator. Whilst liver transplant is a well-established treatment for end stage liver disease (ESLD) in CF, there are few reports of simultaneous pancreatic transplant in the paediatric population. We report the nutritional and endocrine outcomes of two adolescent CF patients who underwent combined liver and pancreas trans...

Endometriosis is one of the commonly occurring disorders of reproductive women, which represents attachment of functional endometrial cells and tissue outside the uterine cavity, culminates into infertility. This invasive disorder is still under quest for novel treatment strategies. Naringenin is a plant-derived flavonoid having anti-proliferative, anti-inflammatory, and anti-angiogenic properties in chronic and metabolic diseases. The study was planned with an objective to de...

Introduction: Hyperglycaemic Hyperosmolar State (HHS) is characterised by Hypovolemia, marked hyperglycaemia, Osmolality of 320 mosmol/kg or more with the absence of acidosis and hyperketonaemia (Ph > 7.3, bicarbonate > 15 mmol/l). This is a presentation usually found in people with poorly controlled Type 2 Diabetes Mellitus (T2DM). During the current pandemic of COVID-19, there have been atypical and unusual presentations of Diabetic Emergencies, in patients with well...

Introduction: Cushing’s syndrome(CS) is associated with high morbidity and mortality which warrants a good screening test that is less laborious. We explored the possibility of using urine spot cortisol:creatinine ratio (UCCR) as a new screening test for Cushing’s syndrome.Aims and objectives: To study the efficacy of UCCR as a screening test for patients with Cushing’s syndrome.To compare UCCR in patients with CS, o...

Congenital hyperinsulinism (CHI) is a clinically and genetically heterogeneous disease. The clinical heterogeneity may range from mild subtle hypoglycaemia to severe life threatening hypoglycaemia. The commonest genetic cause of congenital hyperinsulinism are mutations in the genes ABCC8 and KCNJ11 encoding the two subunits (SUR1 and Kir6.2 respectively) of the pancreatic β-cell KATP channel. In the Ashkenazi Jewish population two founder mutation...

Background: Low testosterone levels are a common finding in men with type 2 diabetes and are also associated with low HDL cholesterol (HDL-C) levels which are an independent risk factor for cardiovascular disease. The androgen receptor CAG repeat polymorphism (AR CAG) and GGN repeat polymorphism (AR GGN) affect receptor function such that shorter AR CAG and AR GGN=23 are associated with greater transcriptional activity in vitro.Methods and results...