Endocrine Abstracts

UNUSUAL PRESENTATION OF DIABETES FOOT ULCERAM Mousa, G Knight, S Muzulu, J R Rochester. Rotherham General Hospital, Moorgate Road, Rotherham S60 2UD.IntroductionPhalangeal metastases commonly display inflammatory symptoms that mimic an acute infection. We describe a rare case of bronchogenic carcinoma with metastases to the left 3rd and 4th toes, which presented as presumed diabetic foot ulceration.<p cla...

IntroductionPrimary Hyperparathyroidism (PHPT) has a prevalence of 1/1000, with only 20% of patients being symptomatic, and was previously considered to be a benign condition. Recent evidence shows increased mortality in PHPT patients, primarily from cardiovascular disease, peptic ulcers and osteoporotic fractures. Parathyroidectomy reduces mortality in PHPT patients. High parathyroid hormone (PTH) levels may increase mortality independently of raised ca...

Urticaria and pruritis are rare skin manifestations of thyrotoxicosis, we present a case where the presenting symptom was generalized distressing urticarial rash.CaseA 39-year-old male presented with a history of itchy urticarial rash all over the body, treated unsuccessfully with antihistamines. Ten weeks after its onset he developed weight loss, palpitations and irritability. Blood tests showed him to be thyrotoxic (TSH 0.02 mIU/...

Theca cells are indispensable for female reproduction being the source of androgens required for follicular oestrogen synthesis and also for interacting with androgen receptors in the ovary and other somatic tissues. Differentiated theca interna cells acquire responsiveness to LH and other endocrine signals, including insulin, that upregulate the steroidogenic pathway leading to androgen biosynthesis. In addition, numerous intraovarian factors of thecal, granulosal and/or oocy...

Background: Neuroendocrine tumours (NETs) arise from neuroendocrine cells, they are commonly found in the pancreas, small bowel and lung. They are a heterogeneous group of tumours capable of secreting a variety of hormones, therefore the spectrum of symptoms is broad. Treatment options for metastatic NETs include cytoreductive surgery, or interventional radiology procedures such as transarterial embolization (TAE). Aims: Previous studies have shown that ...

Secretion of LH and FSH from the anterior pituitary are regulated by hypothalamic GnRH and TGF beta-superfamily members, inhibin and activin. The aim of this study was to identify expression of key receptors in the pituitary gland and monitor their expression throughout the 24-25h ovulatory cycle.Hens maintained on long days (16L:8D) were killed by cervical dislocation 4h, 12h, 18h and 22h after predicted ovulation of a midsequence egg (n=8 per group). P...

IntroductionPhalangeal metastases commonly display inflammatory symptoms that mimic an acute infection. We describe a rare case of bronchogenic carcinoma with metastases to the left 3rd and 4th toes, which presented as presumed diabetic foot ulceration.Case ReportA 74-year-old diabetic man presented with painful, inflamed and ulcerated left 3rd and 4th toes. A clinical diagnosis of infected diabetic toes was ...

Introduction: A breech presentation occurs in 3–5% of all full-term pregnancies and is associated with increased risk of maternal and foetal morbidity. Factors known to increase the risk of breech presentation include prematurity, low birth weight and multiple pregnancies. Recent studies suggest maternal thyroid hormone deficiency in late pregnancy may also be a risk factor. Our study aims to assess if a breech presentation at 36 weeks gestation in a healthy singleton coh...

Background: Subclinical hypothyroidism is common in pregnancy affecting about 5% of all pregnant women, and is associated with adverse pregnancy outcomes. There is a general consensus that subclinical hypothyroidism detected during pregnancy should be treated with L-thyroxine (Stagnaro-green et al. 2011, DeGroot et al. 2012). However, it is unclear whether the treatment should be limited only during the pregnancy or continued long-term. Therefo...

As the sensitivity of a single GH test is poor, current NICE guidelines (2010) state that to make a diagnosis of isolated GH deficiency (IGHD), two stimulation tests need to show subnormal peak GH levels. In our centre we use insulin tolerance (ITT) or glucagon stimulation (GST) as the 1st test, and arginine stimulation (AST) as the 2nd test.The purpose of this study was to identify the proportion of children with discrepant test results; and to establis...