Endocrine Abstracts

Background: Subclinical autonomous cortisol hypersecretion is the most common hormonal abnormality in patients with adrenal incidentalomas, which is characterized by subtle abnormalities of the hypothalamic–pituitary–adrenal axis (HPA) due to adrenal autonomy. Possible detrimental effects of subclinical hypercortisolism in these patients are still under investigation.Objective: To investigate the prevalence of the metabolic syndrome (MS) in pat...

Introduction: Type two diabetes (T2DM), is the most common form of diabetes and known to be associated with low-grade inflammation. Since TLR-4 plays an important role in bacteriel recognition of lipopolysaccharide (LPS) and activation of proinflammatory pathways we aimed of to test whether TLR-4 gene polymorphism plays a protective role in the development of T2DM in a pilot Turkish population.Description of methods/design: Blood samples were collected f...

Objectives: Diabetes risk for Asians is related to a greater tendency to adiposity, which increases insulin resistance. Various studies have highlighted the fact that people from South Asia have a younger age of onset of diabetes, greater upper-body adiposity and lower body mass index (BMI) and higher risk compared to those from other nations. Greece has experienced a large wave of immigration from Asian countries, especially Bangladesh. The purpose of this study was to explor...

Objectives: Smoking tobacco is a risk factor for several diseases and has been increasing in many developing countries. Smoking cessation counseling should be a routine component of diabetes care. The aim of the present study was to examine the association between smoking status in two different groups of patients with diabetes: Immigrants from Bangladesh who live in Greece and Greek-born subjects.Methods: A total of 166 immigrants with diabetes (122 wit...

Introduction: Prayer marks (PMs) have been reported in the literature among Muslim prayers. PMs are found most often on the forehead, knees, ankles and dorsa of the feet. The most common changes consist of thickening, lichenification and hyperpigmentation of the skin, the causative factors being repeated pressure and friction during pray.Objectives: Immigrant populations are disproportionately affected by diabetes and its complications. Moreover, diabeti...

Background: TAO is a rare disease, seriously involving 5% of patients with autoimmune thyroid disease. The clinical presentation may be difficult to distinguish from other orbital conditions.Case 1: A 63-year-old woman was admitted to the Neurology Service for worsening diplopia over the previous six months, with a working diagnosis of myasthenia gravis or multiple sclerosis. The Endocrine Service was consulted because of a long history of Hashimoto&#146...

It has been reported recently that selenium (SE) administration over a 6-month period significantly improved the eye involvement in patients with mild GO.Aim: To investigate SE levels in such patients and find out if they differ from controls, finding which might explain the beneficial effect of SE in such patients.Patients: One hundred and four patients (82F) mean age 47.88±827 (S.D.) (range 32–65) with mi...

Introduction: • Vitamin D deficiency is thought to impair insulin action and glucose metabolism.• Migrants who live in Western countries seem to have lower 25(OH)VitD levels, not only from their white counterparts but also from their native populations in their country of origin.Objectives: • We investigated a cohort of predominantly white Greek Caucasian and Bangladeshi immigrant patients with diabetes mellitus in o...

Introduction: Atypical parathyroid tumour (APT) is a rare cause of primary hyperparathyroidism (PHPT) with a frequency of 1.2-1.3%. APT is a lesion with suspicious clinical and histological features of malignancy which does not completely respect the World Health Organization (WHO) criteria for diagnosis of Parathyroid Carcinoma (PC). There is a well-known association with PHT and medullary thyroid carcinoma for multiple endocrine neoplasia. However, concurrence of thyroid pap...

Introduction: Recently, Programmed cell death ligand 1 (PD-L1) inhibitors have been frequently used as promising treatment options for some advanced malignancies. Although immune-related side effects secondary to PD-1 inhibitor treatment are well defined in the literature, data on PD-L1 inhibitors are limited. Thyroid dysfunction was reported in 10% of patients in the clinical study of atezolizumab. We aimed to present a case of severe hypothyroidism-related rhabdomyolysis and...