Endocrine Abstracts

Introduction: GH therapy in children with normal GH peak in stimulation tests (GHST) is still a matter of discussion. Recently, GH deficiency (GHD) has been defined as secondary IGF1 deficiency (IGFD), however GHST still remain the main procedure in diagnosing GHD.The aim of present study was to compare GH therapy effectiveness in the patients with normal results of GHST (normGH) and with isolated partial GHD (pGHD), with respect to IGF-I secretion befor...

Background: Neck irradiadion is associated with several complications including both hypo- and hyperthyroidism. We present a case of severe hypothyroidism, followed 5 years later by thyrotoxicosis.Case description: A 27-year-old female presented with clinical and biochemical thyrotoxicosis (TSH 0.01 μIU/ml (ref. range: 0.27–4.2 μIU/ml); FreeT4 1.58 ng/dl (ref. 0.98–1.63 ng/dl); FreeT3 4.56 pg/ml (ref. 2.6–4....

Introduction.: The diagnosis of GH deficiency (GHD) is based on decreased GH peak in stimulating tests (GHST). Recently, GHD has been re-defined as secondary IGF1 deficiency (IGFD). However, IGF1 may increase during GH therapy in the patients with normal GH peak in GHST, suggesting a diagnosis of non-primary IGFD (npIGFD).The aim of the study was to compare GH therapy effectiveness in children with GHD and with npIGFD (responding to GH administration des...

Introduction: In majority of patients with childhood-onset GH deficiency (GHD), normalisation of GH secretion at the attainment of final height (FH) is observed. However, different criteria for GHD diagnosis may be considered.The aim of the study was to compare the auxological and hormonal data of the patients with persistent and transient GHD, diagnosed according to different criteria.Patients and methods: The analysis comprised 1...

Introduction: Dendritic cells (DCs) are considered as main regulators of immune system. Functional properties of DCs depend on their subtype, maturation status, interaction with other immune cells as well as environmental factors including hormones. Recently, we have shown a direct, independent of TSH, regulatory influence of thyroid hormones on human DCs function. The aim of the present study was to analyze ex vivo the effect of systemically administered TSH on human...

Background: Hyperthyroidism is a common endocrine disorder that is linked to increased cardiovascular morbidity and mortality. Thrombospondin, the matricellular protein, is an important player in the process of cardiac remodelling with complex effects on cardiovascular disease (e.g. prothrombotic and antiangiogenic effects vs potential protective effects in heart failure). Adiponectin is an adipose tissue-derived hormone that shows beneficial effects on atherogenesis, endothel...

Background: The so called “big-big” prolactin, also known as macroprolactin is formed by prolactin-immunoglobulin complexes, and is considered to be biologically inactive. Nevertheless, macroprolactin may cause elevation of serum prolactin (Prl) concentrations measured by standard assays. In women presenting with oligo- and/or amenorrhoea the cause of menstrual irregularity needs to be explained even in the setting of concomitant macroprolactinaemia. We have therefor...

Macroprolactin is formed by prolactin-immunoglobulin complexes and may cause elevation of prolactin (Prl) concentrations, potentially leading to unnecessary investigations and/or treatment. We have endeavoured to assess the prevalence of macroprolactinaemia in euthyroid women with non-toxic goitre and to assess whether autoimmune thyroid disease may result in an increased prevalence of macroprolactinaemia.Material & Methods: We measured serum Prl in ...

Objective: There is no universal consensus as to the criteria of PCOS (i.e. Rotterdam ESHRE/ASRM versus Androgen Excess Society (AES) criteria). Furthermore, androgen measurements within the female range are fraught with several methodological problems. As GnRH stimulation can reveal a relative LH excess, caused by an increased frequency of hypothalamic GnRH pulses, then we have endeavoured to assess gonadotrophin response to GnRH in women with PCOS and healthy controls...

Objective: The presence of a single parathyroid adenoma is a cause of primary hyperparathyroidism in most cases. Minimally invasive parathyreoidectomy is a treatment of choice in PHPT patients and precise localization of the changed parathyroids is crucial for successful removal.The aim of the study was to assess usefulness of parathormone level estimation in the material obtained during FNAB of the focal neck lesions in order to differentiate structures...