Endocrine Abstracts

M O Thorner, University of Virginia, Charlottesville, VA, USA AbstractMichael O. Thorner is David C. Harrison Teaching Professor of Internal Medicine. He previously was Kenneth R. Cripsell Professor, Chief of the Division of Endocrinology and Director of the General Clinical Research Center and Henry B Mulholland Professor and Chair, Department of Internal Medicine at the University of Virginia. He is a fellow of the A...

I would like to present a case of malignant paraganglionoma which first presented as a mass in right clavicle in a 32-year-old female at Cork University Hospital. Her other medical background included Type 2 diabetes controlled on oral hypoglycemic agents and hypertension. On further imaging, she was found to have another mass in peri aortic region and biopsy confirmed the diagnosis and further verified by MIBG scan in March, 2005. Molecular analysis confirmed deletion of exon...

Type 1 diabetes mellitus has received much attention recently as a potential target for the emerging science of stem cell medicine. Advances in islet transplantation procedures now mean that patients with the disease can be cured by transplantation of primary human islets of Langerhans. A major drawback in this therapy is the availability of donor islets, and the search for substitute transplant tissues has intensified in the last few years. This review lecture will investigat...

Background: Hypogonadotropic hypogonadism (HH) is a key cause of absent, partial, or arrested puberty. Individuals with HH experience central disorders of the hypothalamic-pituitary-gonadal (HPG) axis, with deficiency in gonadotropin-releasing hormone (GnRH). This leads to inadequate pituitary gonadotropins (luteinising hormone (LH) and follicle-stimulating hormone (FSH)), resulting in immature gonadal development. It has substantial consequences including inf...

John RG Challis, CIHR Institute of Human Development, University of Toronto, Canada AbstractJohn Challis is currently the Scientific Director of the Canadian Institutes for Health Research (CIHR) Institute of Human Development, Child and Youth Health. He is also Professor of the Departments of Physiology and Obstetrics and Gynaecology at the University of Toronto, Affiliate Scientist of the Samuel Lunenfeld Research In...

Background: Short Synacthen Tests (SSTs) are integral to the diagnosis of Adrenal Insufficiency (AI). A 30-minute stimulated cortisol value is assessed against local assay dependent thresholds to ascertain or exclude the diagnosis. A diagnosis of AI is a life changing event requiring the initiation of life long glucocorticoid replacement therapy for survival. Glucocorticoid replacement is associated with long term morbidity and mortality, including an increased risk of diabete...

Background: Primary aldosteronism (PA) is a common, curable and high-risk subset of hypertension, mandating detection. In all but the most severe cases, learned society guidelines recommend confirmatory testing. Whilst a variety of confirmatory tests exist, data describing their safety are limited. Concerns centre around the potential of some tests to precipitate hypokalaemia or a hypertensive emergency in a patient with PA on sub-optimal anti-hypertensive medication. In this ...

Background: Obesity is increasing in prevalence in younger people, including children and adolescents. Bariatric surgery (BS) is well-established and efficacious treatment for morbid obesity in adults. BS is being performed in younger age groups more frequently.Objective: To describe outcomes of BS under the age of 25 in Emirati individuals having follow-up at Imperial College London Diabetes Centre (ICLDC).Methods: Patients recrui...

Dexamethasone reduces mortality in COVID patients who require oxygen therapy. Dexamethasone-related hyperglycaemia however is a known complication. Capillary blood glucose (CBGs) above 10.0 mmol/l have been linked to increased mortality in COVID patients. Approximately a third of COVID patients with dexamethasone-related hyperglycaemia may develop diabetes later. It is therefore important to manage acute episodes of hyperglycaemia effectively and identify these patients for fo...

Background: Knowledge of glucocorticoid use during acute illness is widely known, however, knowledge of Diabetes Insipidus (DI) is suboptimal amongst healthcare professionals. In 2009, a series of medical and management failures led to the death of 22 year old from DI in a London hospital. Since then increased efforts have been made to raise awareness about the inpatient management of DI and dangers associated with delay and/or omission of desmopressin. An NHS England patient ...