Endocrine Abstracts

Introduction: Phosphatase and tensin homolog gene (PTEN) gene encodes a lipid phosphatase that plays a central role in cell-cycle processes. PTEN hamartoma tumour syndrome (PHTS), caused by the mutation of the PTEN gene, is a diverse multi-system disorder. PHTS is characterised by the hamartomatous growths, increased risk of breast, thyroid, and renal cancers. In terms of thyroid presentation of PHTS, there is up to 75% risk of multinodular goitre and the life...

Background: Polycystic Ovary Syndrome (PCOS) is characterized as a triad of menstrual irregularities, hyperandrogenism and polycystic ovarian morphology. There is a wide variation in Body Mass Index (BMI) for those fitting PCOS criteria; Identifying differences in relation to Lean BMI patients’ endocrine markers such as LH/FSH ratio and other markers could help identify key areas for improved phenotypic classification. We aimed to focus on a sequential co...

Aim: Camps offer valuable opportunities for creating a supportive environment of like-minded people with similar experiences of living with diabetes, thereby promoting self-efficacy, wellbeing and a healthy life style. In the midst of a post-Covid cost of living crisis, finance was identified as a major obstacle for families wishing to attend residential diabetes camps. A sustainable strategy, supported by co-production with young people, was needed to facilit...

Introduction: The misuse or deliberate restriction of insulin for the purpose of weight loss is commonly referred to in the media and on social media as ‘Diabulimia’1, but this is not a medical definition. The relationship that young people with Type 1 Diabetes have with their weight, food and insulin is a commonly discussed, frequently studied but poorly understood issue. Mental health difficulties, especially eating disorders are common amongst adolescen...

The case: The case described is a 49 year old lady referred to emergency department with history of episodic palpitations, headache and sweating with possible weight loss for last 14 years but symptoms now worse in the past few days. Past medical history was significant for modest hypertension with retinal changes treated with Lisinopril. Patient stopped going to the gym recently as it seemed to exacerbate the symptoms. Patient recently registered with a new GP who in view of ...

Introduction: The destination of young people referred from the NHS Gender Identity Development Service (GIDS) to the two paediatric endocrine centres covering England and Wales has not been analysed previously.Methods: 1151 young people identifying as gender variant were referred from GIDS for an endocrine opinion: 827 patients to University College London Hospital (UCLH) from 2008; 324 to Leeds Children’s Hospital (LCH) from 2013. Outcomes were no...

Background: Childhood growth monitoring aims to identify growth failure and detect underlying pathology. According to UK guidance, height <-2.7 standard deviation score (SDS) (<0.4th percentile) is used as the referral threshold. Additional referral criteria include height deficit (HSDS-target height SDS) <-2.0 and height velocity (HV) SDS <-1.3. Lack of routine HV and mid-parental height calculation, combined with stricter cut-offs compared to other European c...

Background: The transition period is a challenging time for adolescents and is frequently associated with deterioration of HbA1c, decreased attendance, and disengagement from services. Two London hospitals both have existing transition programs to facilitate the movement of patients with diabetes from paediatric to adult care services.Aim: This audit aimed to assess mean HbA1c values, HbA1c monitoring frequency, and appointments offered and attended in t...

Introduction: Bolus calculator glucose meters (BCGM) facilitate self-management of patients with type 1 diabetes (T1DM). However, their effectiveness is dependent on the accuracy of the data entered, use of their smart functions and adherence to the insulin dosages advised. This study investigates whether optimising the use of BCGM is associated with better glycaemic control in children and adolescents with T1DM, and obstacles to preventing their effective use.<p class="ab...

Introduction: Doxycycline is a broad-spectrum antibiotic that is used to treat gram negative, gram positive and atypical bacterial infections. It is a member of the second-generation tetracycline class of antibiotics.Case: We describe a case of a (non-diabetic) male patient who developed hypoglycaemia following treatment with doxycycline. A 73-year-old male presented to the emergency department following a witnessed collapse at 9am on the 4tho...