Endocrine Abstracts

Introduction: The ultimate goal of a diabetes transition service is to provide coordinated, uninterrupted and developmentally appropriate healthcare, which promotes skills in decision-making, communication, autonomy, and self-care, with an essential component required to achieve this, being adequate resourcing.Methods: Data from Yorkshire and South West London CYP diabetes networks were collected via questionnaire. The primary focus was to ascertain whic...

GHI is a genetic condition in which patients present with growth failure due to primary IGF1 deficiency caused by a defect in the GH-IGF1 axis. In the last 10 years in the Centre for Endocrinology of WHRI at Barts and the London, 24 causative mutations in genes of the GH–IGF1 axis have been determined in 58 patients (Table 1). STAT5B mutations were responsible in 2 cases, IGFALS in 4 but the majority of defects identified were in GHR. Most mutations identifi...

Introduction: Diabetes has been associated with poorer outcomes with COVID-19 infection, but precise predictors of mortality in patients with diabetes remain unclear. We assessed predictors of adverse outcomes in patients hospitalised with COVID-19 in Imperial College Healthcare NHS Trust (ICHNT) hospitals during the first and second waves of COVID-19 to determine if outcomes for patients with diabetes have evolved with new variants and treatments.Method...

Background: Lipoatrophy (LA) was commonly associated with insulin use prior to the development of purified insulin in the 1970’s, and then has virtually disappeared. In the last few years, however reports of LA among patients using analogue insulin preparations have increased. We report a case series of 4 patients from a tertiary paediatric diabetes unit presenting with LA while on treatment with analogue insulin via a continuous s.c. insulin infusion pump (CSII).<p c...

The association between hypomagnesaemia and proton pump inhibitors (PPIs) has been well-established in recent years, with a median onset of electrolyte disturbance around 5.5 years after PPI initiation. The mechanisms and aetiology of this potentially life-threatening side-effect remain unclear. We assessed the prevalence of PPI usage in all cases of severe hypomagnesaemia (defined for the purposes of the study as a magnesium level <0.4 mmol/l) in our hospital over the cou...

Introduction and aim: In the UK, 15% of couples are affected by infertility which is due to primary or secondary male factors in 30%. Induction of spermatogenesis with gonadotrophins is a long established endocrine treatment for gonadotrophin deficiency. However, there are concerns that some patient groups have very low success rates. The aim of our audit was to define success of spermatogenesis and fertility rates amongst these men.Methods: We retrospec...

Aims: Type 2 diabetes (T2DM) now affects a significant proportion of young people worldwide. ‘X-borough’ contains a strikingly young, diverse population with one of the highest rates of prevalence for adult T2DM in the UK. Our aims were to determine the prevalence and examine the characteristics of young people with T2DM in this population.Methods: Forty-four young people (<25 years) with T2DM were matched with an equal number of young peop...

Introduction: Epidemiological evidence suggests that vitamin D (25(OH)D3) deficiency is an acquired risk factor for tuberculosis (TB). Lack of sunshine during the winter reduces 25(OH)D3 levels markedly, but darker skin pigmentation reduces 25(OH)D3 synthesis in African and Asian populations wherever they live.Aims: To examine 25(OH)D3 deficiency and its associations in TB patients in a regional population.Methods: Serum 25(OH)D3 c...

Background: We have seen an increased referrals to endocrinology because of adrenal lesions that are discovered on imaging performed for other clinical indications. This is largely driven by the increased use of, technological advancement in imaging modalities, and increasing prevalence of chronic disease. We performed an audit to determine the incidence of adrenal incidentalomas at a large general hospital and to assess management of adrenal incidentalomas in relation to the ...

Purpose: There is increasing evidence that a multidisciplinary (MDT) approach optimises diagnosis and management in active Thyroid Eye Disease (TED) and is recommended by current TEAMeD-5 guidelines1. Here we aim to describe the clinical and endocrine characteristics of a large cohorts of patients with TED seen in 3 MDT clinics in London.Methods: A retrospective patient-cohort study of 236 patients with suspected TED referred to these services...