Endocrine Abstracts

Burosumab, monoclonal antibody targeting fibroblast growth factor 23, is now available for clinical use in children with X-linked hypophosphatemia (XLH). We explored the effects of this treatment in a clinical setting, considering biochemistry, growth, deformity, functionality, quality of life, pain and fatigue.Methods: Clinical, biochemical, radiological and questionnaire data were reviewed at 6 and 12 months(m) for 8 children with XLH starting burosuma...

Introduction: The telephone endocrine clinic (TEC) was established as an adjunct to the face-to-face endocrine clinic to follow and monitor the progress in a selected group of patients after they were seen in main endocrine clinics. This model of care has been tried successfully in other specialities but not as widespread in endocrinology. We audited the effectiveness of TEC and patient satisfaction. Methods: A retrospective analysis of records of all patients contacted in TEC...

Background: Thyroid cancer commonly presents as a new palpable thyroid nodule or increase in size of a pre-existing nodule. A multidisciplinary thyroid lump clinic was established in September 2008 enabling patients to have one-stop clinical, biochemical, radiological and cytological assessment for evaluation of thyroid nodules. This audit predates this period, aiming to provide background information for future audit.Aim: To evaluate the requests for th...

Dynamic pituitary testing is a time consuming and high cost investigation. For effective use of this procedure a close audit of the effectiveness and outcome of testing is required. At UCH we have developed a streamlined nurse led service with medical supervision and we now present an audit of 1 year of testing.Forty-one patients underwent pituitary function testing for growth hormone (GH) and ACTH during 2006. Referral source was from the endocrine team...

An underlying genetic/endocrine cause for severe hypospadias is found in up to 20% of affected boys as described in the literature, with environmental and epigenetic factors also believed to play a role. We conducted a retrospective analysis of 65 boys with severe hypospadias (penoscrotal, scrotal, perineal) managed by Paediatric Urology at Barts Health NHS Trust, born between January 2010 and 2021 (38% white caucasian, 28% asian, 22% black and 12% other/undefined). Boys with ...

Background: Hypothyroidism may profoundly alter mental function and influence mood and cognition, but the neural correlates of these impairments and of thyroid hormone treatment are not well understood.Methods: We prospectively studied 24 subjects, 14 previously untreated newly diagnosed hypothyroid patients (age 42±12 yrs; 11 female, 3 men) and 10 euthyroid control subjects (41±12 yrs). All patients underwent comprehensive neuropsychiatric ass...

Parathyroidectomy is the only definitive cure for primary hyperparathyroidism (PHPT). The standard for pre-operative localisation of parathyroid pathology at our institution is both a (99m)Tc-sestamibi SPECT/CT (sestamibi) and neck ultrasound scan (USS). The aim of this audit was to assess the accuracy of this standard pre-operative imaging.Methods: Retrospective data was gathered from all parathyroidectomies performed at St Thomas’ Hospital between...

Introduction: Germline inactivating mutations of the protein kinase A (PKA) regulatory subunit RIα (the PRKAR1A gene) cause primary pigmented nodular adrenocortical disease (PPNAD); other cyclic AMP (cAMP) signalling defects have been associated with bilateral adrenocortical hyperplasia (BAH), cortisol-producing adenoma (CPA) and related lesions. Recently, PRKACA somatic mutations were detected in single, sporadic CPAs in approximately 40% of patients wi...

Steve Shalet, Dept of Endocrinology, Christie Hospital, Manchester, UK AbstractAfter completing a BSc in Physiology at London University in 1966, I qualified in medicine at the Royal London Hospital in 1969. Junior hospital medical training posts in London and Bristol were followed by an appointment as Research Fellow in Endocrinology at the Christie Hospital, Manchester in 1974....

This abstract has been withdrawn at the request of the first author and Imperial College London. 08/06/2022...