Endocrine Abstracts

Long-acting somatostatin analogs are now increasingly being prescribed as adjuvant and primary therapy for the treatment of acromegaly. Many studies have shown them to be both effective and safe, by suppressing GH levels and normalizing serum IGF-1 levels in most cases.The aim of the study was to analyze the case report of a female patient with active acromegaly and evaluate the efficacy of long-acting synthetic analog of somatostatin (Sandostatin LAR) for biochemical control ...

Introduction: Hypopituitary patients receiving conventional hormone substitution, but without GH replacement, have an increased mortality from cardiovascular diseases. Inadequate hormone replacement is a possible cause of this increased mortality. GH deficiency in adult patients has been associated with several cardiovascular risk factors, including hyperlipidemia, increased abdominal adiposity, and impaired insulin sensitivity.Aim of the study: The aim ...

Purpose: We sought to determine if in the group of patients who underwent gynecologic abdominal interventions diabetes was an independent risk factor of perioperative complications.Material and methods: The study group included 62 women from both the diabetic and the control group who underwent elective gynecologic laparotomies such as hysterectomy or adnexectomy. The patients from diabetic group were pair-matched with patients without diabetes based on ...

Introduction: Neurohormonal diabetes insipidus (DI) is a rare disorder caused by partial or total vasopressin deficiency which results in diluted urine characterized by polyuria and polydipsia. In 30–50% of the cases the cause of the disease is unknown; it is the so-called idiopathic diabetes insipidus. Other causes include: tumors of the CNS most commonly craniopharyngioma, pituitary macroadenomas, central nervous system trauma, inflammatory state of hypothalamus or pitu...

Introduction: Autoimmune polyglandular syndrome type 2 (APS type 2) is co-occurrence of primary adrenal insufficiency (Addison disease) and autoimmune thyroid disease – most commonly Hashimoto thyroiditis (Schmidt syndrome). If it is associated with type 1 diabetes mellitus it is known as Carpenter syndrome. We present clinical pictures of two 33-year-old patients (born in 1980) diagnosed with APS type 2 manifested as Carpenter syndrome to emphasize different courses of t...

Introduction: The severe course of hyperandrogenism during the menopausal transition requires the exclusion of androgen-secreting tumors.Case report: A 60-year-old postmenopausal woman was referred to the Department of Endocrinology with a 3-year history of progressive development of hyperandrogenism with virilization (severe hirsutism, frontal balding, deepening of voice, increased muscle mass, and secondary polycythemia).Hormonal...

Objective: The aim of the study was to evaluate distribution of circulating adiponectin (AdipoQ) isoforms at pregnant women with gestational diabetes mellitus (GDM) and comparison analysis of isoform distribution changes 12 months after delivery.Design: The study was conducted on 64 pregnant women who underwent routine pre-natal tests for GDM between 24 and 28 week of gestation and 30 of them 12 months after delivery. The study group included 36 women di...

Introduction: Hypopituitary patients receiving conventional hormone replacement, but without GH replacement, have an increased mortality from cardiovascular diseases. Inadequate hormone replacement is a possible cause of this increased mortality. GH deficiency in adult patients has been associated with several cardiovascular risk factors, including hyperlipidemia, increased abdominal adiposity, and impaired insulin sensitivity.The aim of the study is an ...

HAIR-AN is a rarely recognized syndrome which is characterized by hyperandrogenism (HA), insulin resistance (IR) and acanthosis nigricans (AN). In the course of the syndrome, anovulation and metabolic disorders can develop, too. It is therefore suggested by some authors that HAIR-AN is an extreme phenotype of the polycystic ovary syndrome (PCOS). Generally, considering wide spectrum of metabolic and endocrine disorders which can be associated with the syndrome, it still remain...

Introduction: Graves’ orbitopathy (GO) is a rare autoimmune inflammatory disease occurring in 25–50% cases of Graves’ disease (GD). It is associated with poor clinical outcomes, impaired quality of life and socio-economic status. Genetic, environmental and immunological factors are considered to play a role in the pathogenesis of GO, but the effects of neutrophil, lymphocyte counts as well as neutrophil-to-lymphocyte ratio on the pathophysiology of GO are still ...