Endocrine Abstracts

The short-term results of transsphenoidal surgery as initial treatment for acromegaly were analyzed according to consensus defining the criteria for cure of acromegaly.Thirty nine newly diagnosed patients with acromegaly (20 females and 19 males, mean age 46.9 plus/minus 1.4 years, range 29-66 yrs), underwent transsphenoidal pituitary adenomectomy by the same neursurgeon. Patients have been assessed postoperatively at 8 weeks (GH after 75 g oral glucose ...

Objective: People are at higher risk for malignancy as they get older or have a strong family history of cancer.Aim: To collect family history of cancer in a large cohort of patients with pituitary adenomas (PA) in Outpatient clinic from years 2005–2017.Results: Overall 46% of 1100 patients with PA had a family member affected with cancer. Breast cancer in family members was reported in 15.3% of patients with prolactinomas whi...

Herein, we have tested the effects of application of commercial soy extract, rich in estrogen-like isoflavones, to orchidectomized adult rats (the model of mild andropause), on the corticosteroid secretion. Exploited animal model provides the opportunity to examine the potential effects of steroid-like compounds in the hormonal milieu deprived of endogenous sex steroids along with preserved hippocampal and hypothalamic regulation of the adrenal gland function. The experimental...

Introduction: Pregnancy and lactation-associated osteoporosis (PLO) is a rare condition in which women have fragile fractures associated with significant reduction of BMD during pregnancy or postpartum period.Case report: A 37-year-old female patient was admitted at our Clinic for further investigation of aetiology of osteoporosis in July 2019. Soon after delivery in February 2019 patient had felt left hip and foot pain as well as sharp intensive pain (i...

Introduction: Previous studies reported increased unfavorable metabolic phenotype in patients with active acromegaly.Aim of the study: We studied the metabolic phenotype in unselected cohort of 133 patients with active acromegaly (83 female, 62.4%), diagnosed at Clinic of Endocrinology, University Clinical Center, Belgrade, Serbia in the period 2007–2018. Mean age at diagnosis of acromegaly was 50.5±1.2 years and mean BMI was 28.4±0.4 kg/m...

Glucocorticoids affect the growth and maturation of fetal organ systems, but overexposure to exogenous glucocorticoids retard fetal growth and may alter developmental process in sensitive tissues. On the other hand, fetal ovary is not characterized by definitive follicular structure, but the clusters of germinative cells are predominant. Germ cells may be in meiotic prophase or with sign of degeneration.The aim of this study was to determine whether pren...

Introduction: Skeletal complications of acromegaly are among its most persistent and invalidating impacts. Dual-X-ray absorptiometry (DXA) alone might be insufficient or even misleading for bone health assessment in acromegaly.Patients and methods: Patients with acromegaly (N=170) were classified as active (N=104), operatively cured (N=34) or medically controlled (N=32). 57 males and 113 females were included, 52.8 (22...

Aging is a complex process characterized by a progressive decline in cellular function, alterations of the endocrine system and the increased incidence of thyroid diseases. Citrus flavanones naringenin (NAR) and hesperetin (HES) may contribute to maintenance of health at old age however they may also affect thyroid hormone economy. The aim of this study was to test weather NAR or HES administration alter thyroid functioning. NAR or HES were administrated orally (15 mg/kg) to m...

Diosgenin, a steroidal sapogenin of natural origin, demonstrated some therapeutic effects when it comes to the treatment of cardiovascular issues, malignancies and the menopausal symptoms. In this study, we have investigated histological changes and corticosterone secretion of the adrenal gland after diosgenin application in a rat model of the menopause. Middle-aged, acyclic female Wistar rats were divided into control (C; n=6) and diosgenin treated (D; n=6) ...

Introduction: Leptin, adipose-tissue-derived hormone has a prominent role in bone remodeling by activating, through CNS relay, the sympathetic tone which inhibits bone formation. Schizophrenia is a CNS disease associated with low bone mass and changes in bone remodeling. Risperidone, atypical antipsychotic, may be related to increase in body weight (BW). Increased BW is thought to be protective to the bone.Aim: To determine relations between leptin, bone...