Endocrine Abstracts

Introduction: Structural and functional damage of the skeletal system resulting in fractures is a common complication of CD. Due to major effect of glucocorticoids on the trabecular bone, vertebral fractures are a common and severe complication which can lead to disability.Goal: To investigate the prevalence of skeletal complications (osteoporosis, osteopenia, presence of fragility fractures) in patients with Cushing’s disease, as well as gain insig...

Objective: Ionized calcium via calcium sensing receptors (CaSR) mediates feedback inhibition of parat hormone (PTH) secretion. The aim of this study is to evaluate the difference in PTH response during calcium infusion test (CIT), between patients with primary hyperparathyroidism (PHPT) and healthy control (HC).Methods: Study consisted of 15 patients with confirmed PHPT and parathyroid adenoma (57.20±11.38yrs) and 15 healthy subjects-HC (57.20±...

Background and aim: Aryl hydrocarbon receptor-interacting protein (AIP) is evolutionary conserved and widely distributed throughout organism. Broad interest for AIP comes from involvement of loss-of-function AIP mutations in pituitary adenoma pathogenesis. The role of AIP in normal pituitary function is largely unknown. AIP is co-localized with GH in somatotroph secretory vesicles. Serum AIP protein was proteomically identified. We aimed at investigating whether AIP and GH are...

Introduction: Selenium (Se) is a trace element that plays key roles in thyroid pathology. In patients with Hashimoto thyroiditis (HT), Se supplementation might reduce antibody levels and may provide additional beneficial effects, such as on cognition.Aim: To evaluate cognitive function (cognitive decline) in patients on long-term levothyroxine replacement for primary hypothyroidism with and without selenium supplementation.Design: ...

40-year-old female patient presented with acromegaly in 2008 (GH 61 (g/L, IGF-1 774 ng/ml PRL 1500 mU/L). Macro-adenoma invading the right cavernous sinus was found on MRI and she underwent two pituitary surgeries revealing sparsely granulated GH adenoma with scattered PRL cells, low Ki 67 and negative p53 immuno-staining. Her second cousin was treated for macro prolactinoma. Both patients tested negative for germline mutations in the AIP and menin genes. Treatment with somato...

Objective: Hypopituitarism is a rare disease,a pituitary adenoma and is treatment being the most common cause of it. In recent years there is increased reporting of rare causes of hypopituitarism acquired in adulthood, such as other sellar and parasellar masses, brain damage caused by radiation and traumatic brain injury (TBI), vascular lesions, infiltrative/immunological/inflammatory diseases and infectious diseases. Aim of our study was to increase the awareness to these rar...

Objective: Congenital hypogonadotropic hypogonadism (CHH) results from isolated GnRH deficiency and may present with normal sense of smell (nCHH), anosmia (Kallmann syndrome, KS) or in syndromic forms. Genetic defects are identified in approximately half of CHH cases and oligogenicity is noted in almost 10%. Further, spontaneous reversal of is seen in 15% of patients.Methods: We analyzed the clinical characteristics of 37 Serbian CHH probands (34 sporadi...

Transition from childhood to adulthood is a vulnerable period in all adolescents and particularly inCO-GHD patients. Low bone mineral density (BMD) and body composition alterations are frequently reported in young adults with CO-GHD, but relevant large monocentric studies are lacking.Patients and Methods: In a monocentric, observational, retrospective cross-sectional study conducted from 2005–2019, 107 CO-GHD patients were analyzed (17–26 yea...

Objective: Kisspeptin is hormone involved in the initiation and maintenance of fertility. Placenta is the major source of kisspeptin but its role during gestation is still matter of debate. Studies investigating kisspeptin levels during gestation in patients with diabetes and hypertension are lacking. Our aim was to prospectively evaluate kisspeptin levels in pregnant women with chronic diseases such as IDDM and H.Design and methods: Kisspeptin levels we...

Background: The so-called silent pituitary adenomas are a subtype of pituitary tumors showing positive immunoreactivity for one or more pituitary hormones, but without any clinical manifestations for oversecretion of these hormones. They are clinically labeled as non-functional pituitary adenomas (NFPA), some of them with particularly aggressive behavior. Rare patients might present with big plurihormonal pituitary tumors which ‘whisper’ hormones (GH or ACTH) and pro...