Endocrine Abstracts

In acromegalic patients growth hormone (GH) excess induces insulin resistance but whether this is sufficient, in the face of normal insulin secretion, for pre-diabetes (impaired fasting glucose (IFG) and impaired glucose tolerance (IGT)) to occur is a matter of debate.Aim: To assess the relative role of insulin resistance and insulin secretion in the pre-diabetes of acromegaly.Methods: One hundred and twenty-four patients with acro...

Aim: To set up, in acromegaly without diabetes mellitus, a correlation between the disease activity in GH-secreting adenoma (AA) - assessed by minimum GH serum level during an oral glucose tolerance test (OGTT) - and severity of insulin resistance (IR), assessed by HOMA-IR index.Methods: 75 out of 88 consecutive patients with acromegaly hospitalized in our department were included in this study. 13 patients proved to have diabetes mellitus and were exclu...

Introduction and objective: This study aims to report if hormone therapy modifies sleep architecture and dreams in menopausal women. Women with no hormone therapy for flushes usually present sleep deprivation and daily sleepiness as a result of nocturnal arousals. Estrogen and progesterone brain receptors can influence memory and cognition processes. Dreams modulators are cognition, socio-cultural factors, personality and brain physiology (REM/NREM percents, circadian influenc...

Background: Almost all patients with Multiple Endocrine Neoplasia, type 2A (MEN 2A) have MTC. C-cell hyperplasia develops early in life and can be viewed as the precursor lesion for MTC. Children with MEN2A who have a total early thyroidectomy have an excellent chance of remaining disease-free.Objectives: To follow-up the children with RET mutation in a family with MEN2A.Methods: We report a family with MEN2A in which the first pat...

Background: Excess mortality after hip fracture remains a problem of public health concern. Until present, for Romania no data is available regarding long term mortality rate and excess mortality after hip fracture. We aimed to evaluate the mortality rate 3 years after hip fracture and also standardized mortality rates of osteoporotic hip fracture in the capital city of Romania and suburban area.Methods: we collected data from over 98 % of fractures admi...

Background: PA is a clinical syndrome secondary to hemorrhage or infarction of pituitary tumour, presenting with sudden onset headache and oculomotor palsy. PA may be managed conservatively in patients without visual disturbances.Aim: To describe PA patients illustrating typical aspects and peculiarities.Results: Case 1, a 49 years old (yo) male, presented for loss of consciousness in the ER. MRI showed a giant pituitary tumour, wh...

Introduction: Acromegaly has various complications that significantly alter patients’ lives, one of which is developing neoplasia, a subject of high interest in the scientific community during the last years but without any firm conclusions.Aim: The main objective of this paper was to verify if Romanian acromegalic patients are susceptible to developing neoplasia and what types of tumors are associated with acromegaly. Another purpose of the paper w...

Background: Active acromegaly is characterized by decreased insulin sensitivity (ISen). However, insulin secretion (ISec) may not increase satisfactorily to compensate for the low ISen.Aim: To assess ISen and ISec and to calculate disposition index (DI) using an intravenous glucose tolerance test (IVGTT) in patients with active acromegaly.Methods: Twelve patients (7 men, 5 women) with active acromegaly and 2 normal subjects (2 men)...

Background: Thyroid nodules were reported with high prevalence in acromegalic patients.Patients and methods: 63 acromegalic patients (16 males and 47 females), aged at diagnosis 43.6±12.7 years were retrospectively reviewed. Median duration of acromegaly was 8 years. 25 patients were residents in iodine deficient areas. GH, IGF1, TSH, FT4 were measured by chemiluminescence (Liaison). Thyroid ultrasound was performed. In suspected nodules,...

Introduction: The most common cause of Cushing’s disease is ACTH secreting tumours of the pituitary gland. It is associated with high morbidity and mortality. Pasireotide, a potential therapy, has a unique, broad somatostatin-receptor–binding profile, with high binding affinity for somatostatin-receptor subtype 5.Case report: We present the a 40-years-old man diagnosed in 2005 with Cushing’s Disease for which a left adrenalectomy was perfo...