Endocrine Abstracts

Introduction: The pituitary tumors which are considered pituitary incidentalomas are accidentally discovered at pituitary scan and they associate a lack of pituitary hyper-secretion. Opposite to what generally are considered for adrenal incidentalomas, the pituitary incidentalomas are more frequent with years of life.Aim: We analyzed the incidentaloma sizes related to decades of age.Material and method: This is a retrospective stud...

Background: Acromegaly is associated with increased prevalence of thyroid diseases, particularly of differentiated thyroid carcinoma.Aim: To assess prevalence of thyroid diseases and thyroid cancer in patients with acromegaly.Patients and methods: Forty (10 M/30 F) acromegalic patients, 14 residents in iodine deficient areas, aged 47±12.8 years, were retrospectively reviewed. Mean duration of acromegaly was 7.6±9.5 years ...

Background: Hyperthyroidism is widely known to be an important cause of secondary osteoporosis through the accelerated rate of bone turnover, while primary hyperparathyroidism is typically associated with loss of cortical bone and less so of trabecular bone, as seen on dual-energy x-ray absorptiometry (DXA). The evaluation of bone quality in these categories is not fully understood and needs further research. The aim of this study was to compare the bone quantity and quality, ...

AbstractThyroid angiosarcoma is an aggressive and very rare type of thyroid malignancy originally diagnosed in iodine-deficient areas. The prognosis is poor and in most cases surgery proved to be inefficient. The fine needle aspiration biopsy (FNAB) and histology can rarely differentiate angiosarcoma from anaplastic carcinoma, and the final diagnosis is based on immunopositivity for vascular markers and absence of epithelial markers. We present he...

Background and aims: Ovarian reserve screening is considered to play a key role in the prediction of quantitative and qualitative aspects in assisted reproductive technologies (ART). The ovarian reserve markers currently used include the serum levels of FSH, oestadiol, inhibin B, anti-Müllerian hormone (AMH) as well as ultrasound antral follicular counts (AFC). Despite controversial results, most of the existing studies suggest that, compared to other markers of the ovari...

Thyroid lymphoma accounts for less than 5% of thyroid malignancies. The aim of this study was to analyze the particularities of 9 patients (7 females and 2 males, aged 42 to 76 years) diagnosed with thyroid lymphoma, representing 2.45% of 340 cases of thyroid malignancies. Patients were assessed by ultrasound examination (7 cases), fine needle biopsy (FNB) (8 cases), lymph node biopsy (2 cases), and histological examination after surgery (7 cases). Clinically, 6 cases presente...

Some patients with pituitary adenomas show high CSF levels and/or high CSF/serum ratio for peptidic pituitary hormones (PR), potentially due to a blood-brain barrier (BBB) damage. We evaluated albumin.CSF/serum ratio (AR) in patients with pituitary adenomas and elevated PR, as an accurate index for a BBB damage.Patients and methods: We evaluated 10 controls (21–79 years, 6M /4 F) before undergoing abdominal or peripheral surgery and 52 patients with...

Background: There is a large agreement that most of the incidentally discovered, clinically mute adrenal masses are incidentalomas - non-functioning tumours, which have to be explored in order to differentiate the adrenal carcinoma.Material and methods: We studied the prevalence and characteristics of clinically mute adrenal tumours and the evolution of adrenal incidentalomas, with the approval of the local Ethical Committee, in 123 patients with adrenal...

Background: End stage renal disease is usually associated with high serum parathyroid hormone (PTH) and increased bone turnover. The aim of our study was to correlate serum PTH with serum markers of bone turnover in patients with end stage renal disease (ESRD).Methods: We measured serum PTH, osteocalcin, procollagen type 1 n-terminal propeptide (P1NP) and beta-crosslaps in 64 (32 men) consecutive pacients, median (25, 75 percentile) age 61 (49.5, 65.5) y...

Background: Growth hormone, age, sex, genetics or nutrition status play an important role in insuline-like growth factor 1 (IGF-1) liver production and serum levels. Currently, there is no IGF-I reference range for Romanian population.Aim: To define sex- and age-adjusted reference values for serum IGF-I measured by an automated chemiluminescence immunoassay in adult Romanian population of healthy subjects.Methods: The study include...