Endocrine Abstracts

GH and insulin-like growth factor 1 (IGF1) are known to promote breast carcinogenesis. Breast cancer (BC) incidence in not increased in female acromegalic patients, but mortality is greater as compared to general population. We previously demonstrated that GH/IGF1 excess influences BC response to therapy, possibly accounting for the increased mortality. We indeed showed that GH and IGF1 induce cell proliferation of a BC cell line, the MCF7 cells, providing protection towards t...

Introduction: Considering the high capacity of water transport of Na+/glucose cotransporter SGLT1, the aim of this study was to investigate the potential role the SGLT1 in luminal membrane of ductal cells of salivary glands upon the non-stimulated salivary secretion of diabetic rats. The present study also investigates the presence of glucose transporter GLUT1 in salivary glands of rats.Methods: Non-stimulated salivary secretion and SGLT1/GLUT1 protein (...

Background: Radioactive iodine (RAI) therapy effectively cures hyperthyroidism although a varying proportion of patients need repeat RAI doses. There is no consensus on the timing of redosing for RAI which varies in different centres between 6 weeks and 12 months depending on the perceived time to respond to therapy.Aim: We have undertaken a retrospective study to assess if after the initial RAI dose of 400 MBq a second RAI dose can be administered earli...

Objective: To define the rates of progression to frank hyperthyroidism and to normal thyroid function for subclinical hyperthyroid patients (SH).Design: Record-linkage technology was used retrospectively to identify patients with SH in the general population from 1st January 1993 to 31st December 2009.Patients: All residents over 18 years old with at least two measurements of TSH below the reference range for at least 4 months from...

Metabolic syndrome (MetS) is a clustering of cardio-metabolic risk factors (hyperglycemia, hypertension, dyslipidemia, visceral fat accumulation) that is also associated with hypogonadism and erectile dysfunction (ED). The study was aimed at clarifying the relationships among MetS, hypogonadism, and ED, we developed an animal model of MetS.Methods: Male rabbits fed a high-fat diet (HFD), with or without testosterone (T) supplementation, were compared wit...

A female patient, 34 years old, was referred to endocrinologist, for an incidentally discovered interstellar mass on MR, mild subclinical hypothyroidism and hyperprolactinemia, and irregular menstrual cycles. She was diagnosed with Bloch-Sulzberger syndrome (BSS) in neonatal age. Epilepsy, her most prominent component of BSS, was well controlled but only with triple anticonvulsant therapy (Valproate, Carbamazepine, Clonazepam). She was obese, clinically euthyroid, and exhibite...

The insulin-like growth factors (IGFs) signal through the type 1 IGF receptor (IGFIR) to regulate cellular proliferation and survival. A current theory suggests that a subset of plasmalemmal lipid rafts, termed caveolae, may orchestrate such IGF-mediated signalling.In order to investigate the role of caveolae and the marker protein caveolin in controlling IGF signals, two cell models of caveolin deficiency were generated. Using shRNA, caveolin-1 expressi...

Aims or Objectives: We here describe a role for the kinase thousand and one kinase (TAOK) 3 as a modulator of insulin resistance. TAOK3 is one of three members of the TAOK family of kinases, which are classified within the Ste20-like kinases as mitogen activated protein kinase 4 kinases. TAOK3 was identified in a RNAi library screening in C. elegans as a target molecule that could revert an insulin resistance-like state induced by a daf-2 mutation (Devgen, Ghent). Mor...

Introduction: Even though most hypertensive patients have essential hypertension, in the resistant cases the prevalence of secondary hypertension is much higher; therefore its screening should be mandatory. Resistant hypertension usually causes a progressive decline of renal function if blood pressure is not adequately controlled. Such decline is often irreversible; however a timely diagnosis leading to a resolutive treatment can alleviate or even revert the progression of the...

Case report: We report a young woman with ovarian hyper stimulation syndrome (OHSS), headache, visual field defect and pituitary macro adenoma. The patient was treated about four years ago as pituitary PRL-secreting adenoma with carbergoline. The evaluation of other hormones FSH, LH and Estradiol values wasn’t done. The patient presented to our hospital with abdominal pain and headaches and amenohrrea. The pregnancy test was negative and pelcic ultrasound demonstrated enl...