Endocrine Abstracts

Introduction: Central diabetes insipidus (DI) is observed in up to 34% of patients undergoing pituitary surgery. Early postoperative diagnosis of DI is critical because its detection allows early treatment, reducing morbidity and hospital stay. AVP levels measurement is not commonly used to diagnose DI. As an alternative, copeptin determination has been proposed, but its usefulness has only been validated in one series.Objective: To define the threshold ...

Introduction: In primary hyperparathyroidism (PHPT) medical treatment is indicated if the patient donot carry out the surgical criterion, donot accept surgery or there is another serious comorbidity that makes impossible the intervention. Cinacalcet is a calcimimetic that increase the sensitivity of the calcium-sensing receptor (CaSR) to ionized serum calcium, decreasing secretion of PTH and serum calcium concentration. This drug is prescribed for secondary hyperparathyroidism...

Introduction: Obesity is one of the most prevalent health problems in our society. The marketing of Liraglutide and the Naltrexone/Bupropion combination has been given the green light.Objectives: To analyze the differences in a series of 19 patients assigned to treatment with Liraglutide or Naltrexone/Bupropion.Material and methods: A descriptive analysis was carried out using Stata. 19 patients were included, 9 were treated with L...

Microvascular endothelium is one of the main character and target involved in the inflammatory response. Upon specific activation, endothelial cells massively recruit Th1 IFNgamma secreting lymphocytes at the inflammatory site. In the present study, we investigate the intracellular signalling mediating TNFalpha (T) and IFNgamma (I) inflammatory response in a human endothelial cell line (HMEC-1) in vitro and the interfering effects of rosiglitazone (RGZ), a peroxisome pr...

We present 2 cousin brother and sister, MK and AK (family tree attached in Fig) who presented with a common pattern of hyponatremia with hyperkalemia, hypomagnesaemia, salt wasting, hyperaldosterinism and hyper-reninaemia in their neonatal life with polyuria. A diagnosis of pseudohypoaldosteronism was made and they were commenced on sodium supplements and indomethacin.The shaded boxes are in utero deat...

From a patient's perspective thyroid eye disease is the predominant symptom, and often the eye disease does not revert back to normal even after treatment of the thyrotoxicosis.Thyroid eye disease - is this a life sentence? A patient's experience and viewpoint and an open discussion....

Ghrelin (Ghr) is an orexigenic peptide investigated by Lutter and col. 2008 for its potential role in the development of depressive symptoms induced by chronic stress, suggesting that Ghr defends against depressive-like symptoms. Rodent bilateral olfactory bulbectomy (OB) is an animal model that appears to fulfill many of the criteria required for the study of depression; hence, Ghr could be an alternative therapeutic tool for depression therapy. We study the possibility that ...

Erectile dysfunction (ED) is a multidimensional disorder characterized by the inability to have successful intercourse with negative consequences in personal self-esteem and in couple relationship. Organic, relational and intrapsychic problems always concur in determining the erectile problem, although in different combination according to the patient characteristics, including age. Fifteen years ago, we have developed and validated a structured interview to identify and quant...

Background: Gonadotropin-releasing hormone (GnRH) receptor is a G protein-coupled receptor involved in the synthesis and release of pituitary gonadotropins. GnRH analogs constitute the most widely employed medical treatment for prostatic cancer. The predominant mechanism of action is presumed to be via the inhibition of gonadotropins and resultant decrease in androgen. Although pituitary and extra-pituitary GnRH-R transcripts appear identical, their functional characteristics ...

Despite intense efforts over the past decades, human pancreatic beta cell lines with physiological insulin secretion have not been available. We have developed a robust transplantation model of fetal human pancreases that recapitulates pancreas development and combined such model with integrative lentiviral-mediated gene transfer. This resulted in production of human transgenic pancreases in which dynamic aspects of development can be studied. We thus forced expression of immo...