Endocrine Abstracts

Introduction: miR143 and 145 seem to be involved in the pathogenesis of cortitotrophinomas by modulating the expression of MAPK7 and CCNL1 genes, which protein products are involved in cell proliferation, differentiation, and cell cycle progression. Objective: To analyze the modulation of miR-143 and -145 in the expression of MAPK7 and CCNL1 genes in corticotrophinomas and corticotrophic tumoral lineage (AtT20).Material and Methods: The expression of MAP...

Besides its critical functions as a reproductive hormone, 17β-estradiol (E2), plays an important role in the control of energy homeostasis. In experimental animals, reduction of circulating estrogen levels by bilateral ovariectomy leads to the development of obesity, which can be reversed or prevented by E2 treatment. E2 effects on energy balance resemble many similarities to the actions of leptin, key molecule involved in the control of e...

Repeated exposure to lipopolysaccharide (LPS) leads to endotoxin tolerance. Desensitization of hypophagia in response to repeated exposure to endotoxin is related to an inability of leptin to phosphorylate STAT-3 protein. Protein tyrosine phosphatase 1B (PTP1B) activity is known to contribute to leptin resistance by inhibiting leptin signaling. In this study, we induced endotoxin tolerance, injecting repeated LPS doses (6LPS) (100 μg/kg, i.p.) in comparison with single (1...

Introduction: Multinodular Goiter (MNG) is a thyroid neoplastic disease thirteen times more common in women than in men. While a local effect of estrogens at cellular levels could affect there can be other causes to explain the gender difference in incidence such as diet, environmental factors, genetic causes or alterations in metabolic pathways.Cellular effects of estrogens in human thyrocytes although previously studied are not completely clarified. So...

Introduction: Radiodine (131I) is widely used in the treatment of patients with thyroid cancer. This therapy is associated with some adverse effects including possible impairment of ovarian function and earlier menopause.Objective: The aim of this study was to evaluate female fertility after treatment with 131I of differentiated thyroid cancer (DTC).Methods: We retrospectively analysed 250 women with DTC treat...

Background: The different systems for monitoring capillary blood glucose levels may suffer interference from various substances.Case report: Male patient, 48 years old, with history of hypertension, dyslipidemia and previous smoking. He presented also type 1 diabetes mellitus, with 37 years of progress, with diabetic retinopathy, kidney failure, in peritoneal dialysis since 2009, and ischemic heart disease (myocardial infarction in 2005). He was treated ...

Introduction: Recently, the American Diabetes Association has proposed glycated hemoglobin (HbA1c) as a diagnostic criteria for diabetes (HbA1c≥6.5%) and prediabetes (5.7%≤HbA1c≤6.4%).Aims: To compare HbA1c with fasting glucose and oral glucose tolerance test (OGTT) as diagnostic criteria for diabetes and prediabetes, in obese patients; to calculate its sensitivity and specificity when compared with standard diagnostic criteria.<p c...

Introduction: POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes) syndrome is a rare multisystemic disease. Diagnosis requires two major criteria and at least one minor criterion. Major criteria include polineuropathy and a monoclonal plasma proliferative disorder (almost always lambda). Minor criteria include osteosclerotic bone lesions, Castleman disease, organomegaly (including lymphadenopathy), oedema, pleural effusion or ascites, e...

Introduction: Ectopic Cushing’s syndrome is a rare disease, with a reported incidence of 0.1/million per year. This disorder accounts for approximately 12–17% of patients with ACTH-dependent Cushing’s syndrome. Small cell lung carcinoma is responsible for about 20% of cases, although ectopic ACTH hypersecretion occurs in only 0.5–2% of these tumours. Hypercortisolaemia is usually severe and of rapid onset. Optimal treatment is surgical excision of the tumou...

Introduction: Tyrosine Kinase Inhibitors (TKIs) are approved for the treatment of several cancers and can induce hypothyroidism by unclarified mechanisms.Objectives: To assess the prevalence of hypothyroidism in patients treated with TKIs.Methods: Retrospective review of clinical records of patients treated with TKIs in our institution between 2003 and 2009. We evaluated parameters such as sex, oncologic pathology, TKI used, TSH an...