Endocrine Abstracts

Introduction: Sarcoidosis is a systemic granulomatous disease of unknown etiology with a prevalence of 10–20/100 000 individuals and affects mainly young adults. Neurological involvement occurs in about 5% of the cases and it can affect the hypothalamic–pituitary axis. In this case, the most common endocrine manifestations are hyperprolactinemia and diabetes insipidus.Case report: A 44-year-old male patient complaining of not feeling well and d...

Ectopic ACTH secretion due to malignant tumours is a rare cause of hypercortisolism. Induced metabolic disturbances are often serious and the management of such patients may be difficult. We report the case of a 50-yr-old man who had a sporadic medullary thyroid carcinoma (MTC) removed 2 years ago (Dec/2003). Calcitonin and CEA levels remained high postoperatively and a CT scan revealed liver metastases. In August 2005 he was referred to Endocrinology with symptoms of muscular...

IntroductionIn Klinefelter syndrome, hypergonadotropic hypogonadism is the most prominent endocrine-metabolic disorder. However, a higher prevalence of cardiovascular risk factors has also been reported.ObjectivesIn a sample of individuals with Klinefelter Syndrome (KS): – to document the diagnostic context; – to assess the prevalence of cardiovascular risk factors (CVRF) and compare it with a contr...

IntroductionNoonan syndrome can result from different mutations, the most frequent being in PTPN11. The diagnosis is often made by the clinical picture of short stature, facial dysmorphisms and heart defects. From an endocrine point of view, growth retardation, hypogonadism and a higher frequency of thyroid autoimmunity are highlighted.ObjectivesTo analyse endocrine features in patients with Noonan syndrome (...

IntroductionRadioiodine whole-body scintigraphy plays an important role in the follow-up of patients with differentiated thyroid carcinoma (DTC), as it is highly accurate in detecting thyroid residues and recurrent disease. Unusual 131-iodine uptake outside the thyroid bed and areas of physiological uptake is strongly suggestive of distant metastasis. However, uncommon uptake may occur and lead to diagnostic errors.Case report<...

Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading cause of chronic liver disease (CLD). Screening of liver fibrosis by clinical scores is recommended in people with obesity, but their accuracy is still under discussion. Vibration-controlled transient elastography (VCTE) is among the best validated imaging tools to assess liver fibrosis, and is suggested in patients with indeterminate or high-risk clinical scores....

Introduction: The interaction between obesity and bone metabolism is complex and not fully understood. Historically, higher body weight was considered to be protective against osteoporosis. This association has affected clinical practice: body mass index (BMI) is one of the variables included in Fracture Risk Assessment Tool (FRAX), where a higher BMI leads to a lower fracture risk. Despite this association between bone mineral density (BMD) and body weight, it is not clear wh...

Introduction: Pituitary metastases are rare, accounting for only 1% of intracranial metastases and predominantly originating from breast and lung tumors. Pituitary involvement is observed in only 6–8% of breast cancer cases, with an overall unfavorable prognosis.Case series: A 53-year-old woman, with a six-year history of breast cancer metastasized to the lungs, presented with a three-month history of headaches, visual disturbances, asthenia, weight...

Introduction: Gestational diabetes (GD) is a known risk factor for delivery, fetal and perinatal complications. Fetal male sex is known to be associated with worse perinatal outcomes, such as macrosomia, neonatal hypoglycemia, low Apgar scores, birth defects and mortality. However, studies evaluating the impact of fetal sex on perinatal outcomes in women with GD are scarce. Objectives: We aimed to study whether male newborn sex is associated with neonata...

Introduction: Women with gestational diabetes (GD) have an increased risk of developing future type 2 diabetes mellitus (T2DM). A reclassification oral glucose tolerance test (OGTT) is currently recomended in the postpartum period. However, most studies report a compliance rate below 50% and as low as 23%.Objectives: We aimed to study predictors of missing postpartum OGTT in women with GD.Materials and Methods: Retrospecti...