Endocrine Abstracts

Introduction: Women with Turner syndrome (TS) have an increased risk of diabetes mellitus (DM) the pathogenesis of which is not well understood. International guidelines for TS recommend oral glucose tolerance tests (OGTT) but the utility of this test has not been determined. We sought to establish the rate of IGT and DM and characterise the DM-phenotype in adult women with TS.Methods: We performed OGTTs in 37 adults with TS and obtained an additional fa...

Background: Turner Syndrome (TS) is a sex chromosome aneuploidy (45,X) associated with social skill difficulties. The 2016 Cincinnati clinical care guidelines recommend that the Program for the Education and Enrichment of Relational Skills (PEERS) social skills intervention is piloted. PEERS has previously been used in face to face interventions with male adolescents with autism spectrum conditions. This pilot project will be the first to examine the feasibility and acceptabil...

Objectives: To evaluate sexual function in women with Turner syndrome (TS) in the relation with sex hormones.Methods: The study was undertaken in Lithuanian University of Health Sciences. 65 women with genetically confirmed TS (18–45 years) were enrolled and compared with 65 age-matched healthy controls. Sexual function was evaluated using The Female Sexual Function Index (FSFI). Risk for sexual dysfunction was defined as FSFI score ≤ 26.55. B...

Background: Pubertal induction with incremental doses of oestrogen replacement is an important component of care offered to hypogonadal patients with Turner Syndrome (TS). Low dose oral ethinylestradiol (EE) has been extensively used in the UK but natural 17-β oestradiol (more physiological, cheaper and easily monitored in blood) is becoming increasingly popular. We undertook this audit to compare the efficacy and acceptability of oral (EE) and patch (Evorel) oestrogen pr...

Aim: To evaluate bone mineral density (BMD) in children with different karyotype variants of Turner syndrome (TS) depending on the stage and the onset of puberty (spontaneous or induced).Methods: The total studied group consisted of 75 children with TS from 8 to 17 years (mean age 14.2 ± 2.61), who were regularly followed-up in the University hospital (Minsk) and age matched 25 healthy controls. TS was diagnosed according to the results of karyotypi...

Introduction: Since primary amenorrhea because of ovarian dysfunction is a common complication in women with Turner syndrome (TS), sex hormone replacement therapy (HRT) is mandatory for induction of puberty, such as acquisition of secondary sexual characteristics and increased bone density. However, appropriate treatment protocols have not yet been established. To evaluate the efficacy of HRT on puberty induction in our department, a retrospective analysis was conducted.<p...

Recently updated international guidelines recommend specialist surveillance of adults with Turner Syndrome (TS). In 2005, we established a dedicated TS clinic, attracting referrals from our general endocrine service and other specialities including primary care.Twenty-three patients currently attend of whom 9 were previously under endocrinology review. Karyotypes include 45XO (8/23), 45XO/46XrX (4/23), and 45XO/46XiXq (3/23). Mean (±S.D.</sma...

Children diagnosed with either Growth Hormone deficiency (GHD) or Turner syndrome (TS) are both treated with GH titrated against either weight or area. The response to such treatment however, is highly variable and, at least in part, diagnosis dependent. The precise mechanisms underlying this variability are unknown. As basal GH levels differ between GHD and TS and, as GH elicits its effects through changes in gene expression, the basal gene expression profiles of GHD and TS s...

Dissection or rupture of the aorta accounts for death in 2-8% of women with Turner Syndrome (TS), and dilatation of the aortic root, has been reported as a predisposing factor. We compared measures of arterial structure, stiffness and endothelial function to investigate whether women with TS have a fundamental arterial wall defect which extends beyond the arch of the aorta. Local Ethics Committee approval was obtained.Age-matched women with TS (n=93), 46...

Dissection or rupture of the aorta accounts for death in 2-8% of women with Turner Syndrome (TS), and dilatation of the aortic root, has been reported as a predisposing factor. We compared measures of arterial structure, stiffness and endothelial function to investigate whether women with TS have a fundamental arterial wall defect which extends beyond the arch of the aorta. Local Ethics Committee approval was obtained.Age-matched women with TS (n=93), 46...