Endocrine Abstracts

Rationale: Patients with morbid obesity may have vitamin D deficiency and bariatric surgery may exacerbate it due to factors such as lack of dietary compliance, reduced intake, malabsorption, etc.Objective: To study vitamin D deficiency prevalence in patients with morbid obesity before and after bariatric surgery and its relationship with other laboratory parameters.Methods: A retrospective study of 88 morbidly obese patients befor...

Aim: To analyze the influence of bariatric surgery over serum lipids in patients with morbid obesity after 1 year of surgery.Methods: Retrospective study of 88 patients before and after 1 year of bariatric surgery (65 by pass and 23 sleeve). We collected data about age, sex, other diseases, anthropometric measures and biochemical parameters: glucose, uric acid, total cholesterol (TC), HDL-C, LDL-C, triglycerides (TG), VLDL and non-HDL-C, homocistein and ...

Introduction: Drospirenone is a synthetic progestin usually found in combination with ethynilestradiol in oral contraceptive formulas. In 2007, this compound was also used in hormonal replacement therapy during menopause. Drospirenone shows antimineralocoricoïd effect due to an analogy of structure with aldosterone. This effect counteracts the estrogen stimulating action of renin–angiotensin–aldosterone (RAA) system, lowering water retention symptoms due to clas...

In elderly subjects the mortality rate after hip fractures ranges from 18 to 33% within one year; among survivors, 40% did not return to the previous level of functional ability. The aim of this study was to evaluate the longitudinal changes of some markers of bone metabolism in relation to functional and nutritional status.Thirthy-seven subjects aged more 70y with a new vertebral or hip fracture were admitted to the study. Thirthy age-matched and not fr...

Introduction: Parathyroid carcinoma (PCa) is a rare presentation of primary hyperparathyroidism (PHPT), accounting for less than 1% of cases. Differentiating parathyroid cancer from benign hyperparathyroidism is clinically challenging. Some previous work suggest that there is a paraneoplastic hCG production in parathyroid cancer (Stock et al 1987, Rubin et al 2008). In this study, we aimed to investigate whether the hCG+β kit from Roche Diagnostics could distinguish PCa p...

Objective: IGF1 is the most useful serum marker for GH dose titration in adults. The authors focused on the GH dose adjustment with extreme IGF1 values (<−2S.D.; >+2S.D.).Methods: French observational study of AGHD patients treated with Norditropin®.Prospective follow up until 5 years.Results (median [Q1; Q3]):: 328 AGHD, 39.2±14.3 years old wer...

Introduction: Neurokinin B (NKB) is a neurotransmitter, regulating GnRH. NKB activates its receptor TACR3. Recessive mutations of TACR3 are associated with a phenotype of normosmic hypogonadism.Case report: A 17 years old man born in Turkey, present with pubertal delay. He is treated 3 years with testosterone and he is reevaluated without treatment. He is 1.79 m and 1.85 arm span, testicular volume: 3 and 4 ml. He has no olfactory troubles. Testosterone ...

Introduction: The prolactinoma is the most common functioning pituitary tumour. There are few long-term studies on the optimal duration of treatment with dopamine agonists prolactinoma to ensure healing without recurrence after stopping the medication and do not provide a consensus on it or on withdrawal criteria treatment.Objectives: To establish the prevalence of withdrawal of treatment macroprolactinomas and evaluate criteria prolactinoma cure medical...

Introduction and objective: The aim of this study has been to evaluate the relationship between vitamin D and iPTH levels and the status of carbohydrate metabolism in a representative sample of the Spanish population.Material and methods: The study was conducted in two population of northern and southern Spain, evaluated in the same period of time and with a similar methodology: Pizarra Study (Málaga) and Asturias Study. Subjects in both groups unde...

Background: Vitamin D deficiency is common worldwide. No homogenous reference values have yet been established and no studies of values have been done in Spain involving a large number of participants.Objective: To study the population concentrations of vitamin D in a representative sample of the Spanish population.Subjects/methods: The study involved two cohorts from Spain, the Asturias Study and the Pizarra Study, which are two p...