Endocrine Abstracts

Aim: To evaluate the usefulness of measuring maternal anti-TSH receptor antibodies (TRAbs) and fetal ultrasound (US) monitoring in cases of current or past maternal hyperthyroidism.Materials and methods: A 77 pregnant women with active hyperthyroidism irrespective of its cause or with history of Graves’ hyperthyroidism were observed prospectively. Maternal serum TSH, fT4, fT3, TRAbs, and fetal US were performed at baseline and ...

Introduction: Data regarding the thyroid gland evaluation in Polish adolescents are limited.Aim: The aim of the study was to asses TSH and anti-thyroid peroxidase antibodies (anti-TPO) concentrations as well as thyroid morphology on ultrasound in Warsaw adolescents in regard of family history of thyroid disease.Materials and methods: The study was carried out on a group of 480 adolescents (285 girls and 195 boys), aged 17–18 y...

Background: Primary aldosteronism constitutes the most common form of hormonal hypertension. However, it is often mistreated and widely underdiagnosed. Despite the great progress in laboratory technics of adrenal diseases, in the field of primary aldosteronism there is still a need for novel biomarkers that would clarify the diagnosis in equivocal cases. Adropin is a newly discovered protein that may play a role in glucose metabolism and the development of cardiovascular disea...

Primary hypophysitis (PH) is a rare clinical entity usually presenting with headaches, pituitary deficiency, visual field defects and exceptionally with symptoms of cavernous sinus infiltration such as cranial nerve palsies. An internal carotid artery (ICA) occlusion is unusual complication of PH infiltrating the cavernous sinus. A 32-year old woman presented with a 4-year history of recurring headaches, right retro-orbital pain, periodic diplopia and secondary adren...

Background: Primary aldosteronism (PA) is the most frequent cause of hormonal hypertension, typically associated with hypokalaemia. Whereas hypertension with no hypokalaemia can be present in even half of cases, hypokaleamia in normotensive patients is a very rare finding. Mechanisms that act against developing hypertension despite aldosterone excess are at least a few. Some patients with previous low blood pressure increase its values because of hyperaldosteronism, thus still...

Introduction: Impaired glucose tolerance and overt diabetes mellitus are frequently associated with acromegaly. The aim of this study was to find whether these alterations could be reversed after transsphenoidal surgery.Patients and methods: Two hundred and thirty-nine acromegalic patients were studied before and 6–12 months after transsphenoidal surgery. Diagnosis of active acromegaly was established on the basis of widely recognized criteria. In e...

Introduction: Real-time elastography (RTE) is a noninvasive ultrasound method of estimation of tissue stiffness by measuring the degree of local tissue displacements after a small compression. Recent data has shown indicate on its ability to differentiate benign and malignant tumors. The aim of the study was to evaluate the diagnostic accuracy of RTE in the diagnosis of malignant and benign thyroid nodules.Material and methods: A total of 75 thyroid nodu...

Diagnostic procedures reveal that majority of incidentally found adrenal tumours (adrenal incidentalomas, AI) appear to be benign adenomas. However, AI accompanying malignant tumours must be diagnosed very carefully to take a proper decision concerning their management. In the registry of the Department of Endocrinology in Warsaw, there are 1888 patients (1388 women, 500 men, F/M ratio 2.8) with AI, 10–87 years old. Primary malignant tumours were diagnosed in 155 patients...

Introduction: Transsphenoidal adenomectomy is the treatment of choice in secreting pituitary adenomas with the symptoms of Cushing’s disease, acromegaly as well as few cases of Prolactinoma, which – due to resistance to pharmacological treatment – require surgery. The efficacy of selective adenomectomy ranges from 60 to 95%. It is the highest in patients with well-visualized by MRI microadenomas, lower in macroadenomas and the lowest when the surgery was ...

Adiponectin is a soluble protein produced solely by matured adipocytes. Adipogenesis contributes to the pathogenesis of GO in many ways including a direct effect on proptosis due to increased volume of mature adipocytes.The aim of the study was to estimate an influence of immunosupresive and anti-inflammatory treatment using systemic corticotherapy combined with orbital radiotherapy on serum adiponectin level in GO patients. The study was accepted by Eth...