Endocrine Abstracts

We study the impact of the dehydroepiandrosterone (DHEA) by the women with diminished ovarian reserve and very low DHEA-S in the blood.Patients: We present a description of 7 patients with diminished ovarian reserve (DOR). Patients reported because of problems with getting pregnant. Infertility lasted for several years. The patients disagreed on IVF for ethical and religious reasons. All of the presented patients were diagnosed with diminished ovarian re...

Introduction: Generously supported by IPSEN)-->Impaired glucose tolerance and insulin resistance are frequently associated with acromegaly. The aim of this study was to assess the effect of octreotide-LAR treatment on glucose homeostasis in acromegalic patients.Patients and methods: In this prospective study 16 naïve acromegalic patients were studied before and after 3-month therapy of octreotide-LAR (20 m...

Idiopathic hypogonadotropic hypogonadism (IHH) is caused by an isolated defect in GnRH release or action and classified as the Kallmann syndrome with associated anosmia or normosmic IHH in the presence of a normal sense of smell. Patients with IHH have absent or incomplete sexual maturation and infertility. Usually long term GnRH or gonadotropin therapy in these patients can induce spermatogenesis and puberty and is followed by testosterone therapy to maintain normal virilizat...

About 8–10% of erectile dysfunction (ED) is caused by hormonal causes, but in men over 65 years testosterone deficiency due to aging seems to play important role. In population of Polish men with relative poor health status, the prevalence of testosterone deficiency in elderly men with ED is probably higher. We evaluated the prevalence of low and low-normal testosterone levels in men with ED in population of Polish men over 65 years.Material and met...

Introduction: Impaired glucose tolerance and insulin resistance are frequently associated with acromegaly. The aim of this study was to assess the impact of long-acting somatostatin analog treatment on glucose homeostasis in acromegalic patients.Patients and methods: In this prospective study 16 naïve acromegalic patients (eight females, eight males; aged 51.5±10.9 years) were studied before and after 3-month therapy with long-acting somatostat...

Background: Neuroendocrine tumors awareness is developing. Carcinoid syndrome and hormonal overproduction may be controlled with somatostatin analogues in majority of cases. However, due to unspecific symptomatology in early stages of disease, majority of cases are diagnosed when process is disseminated. Co-morbidities and coexisting diseases are present in most of patients. Bone loss may be accelerated by metastizing tumor, peptides secreted or decreased absorption of vitamin...

Background: Acromegaly is characterized by disabling symptoms and relevant comorbidities. Insulin resistance, leading to glucose intolerance is one of the most important contributory factor to the cardiovascular mortality in acromegaly.Aim: To assess the impairments of glucose homeostasis in acromegalic patients and find association between activity of the disease and the severity of glucose intolerance.Patients and methods: In thi...

Objectives: The aim of this study was to analyze the influence of DHEA therapy on fibrinogen, plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (tPA) plasma concentrations in men with decreased serum DHEAS levels and angiographically verified coronary heart disease (CHD).Material and methods: The study included thirty men aged 41–60 years (mean age 52±0.90 yr) with serum DHEAS concentration <2000 μg/l, who were...

Introduction: In elderly men testosterone and DHEAS deficiency is often observed, also changes of body composition and metabolic disturbances are common disorders.Objectives: The aim of this study was to analyze the association between testosterone and DHEAS deficiency and waist/hip ratio (WHR) and also levels of glucose, insulin, HOMA and FG/FI ratio in elderly men as well as analysis, whether these sex hormones influent on measured parameters separatel...

23-year old man was admitted to Endocrinology Department because of hypogonadism and pituitary tumor seen at CT. Diagnosis of prolactinoma was established based on high serum PRL level- 800 ng/ml and therapy with bromocriptine was instituted. On the next year a temporary loss of consciousness related to physical exertion occured. The neurological reasons were excluded and laboratory tests showed hypercalcemia, hypophosphatemia and elevated serum PTH levels. Prolactinoma and hy...